Recombinant Human Glutathione S-transferase P (GSTP1) | MyBioSource MBS966591 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Glutathione S-transferase P (GSTP1)

catalog :

MBS966591

quantity :

0.5 mg (E-Coli)

price :

960 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS966591

products type :

Recombinant Protein

products full name :

Recombinant Human Glutathione S-transferase P (GSTP1)

products short name :

Glutathione S-transferase P (GSTP1)

products name syn :

Glutathione S-transferase P; EC=2.5.1.18; GST class-pi; GSTP1-1

other names :

glutathione S-transferase P; Glutathione S-transferase P; glutathione S-transferase P; GSTP1-1; GST class-pi; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III; glutathione S-transferase pi 1; GST class-pi; GSTP1-1

products gene name :

GSTP1

products gene name syn :

GSTP1; FAEES3; GST3

other gene names :

GSTP1; GSTP1; PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22; FAEES3; GST3

uniprot entry name :

GSTP1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

2-210

sequence length :

209

sequence :

PPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVTVETWQ EGSLKASCLY GQLPKFQDGD LTLYQSNTIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL RCKYISLIYT NYEAGKDDYV KALPGQLKPF ETLLSQNQGG KTFIVGDQIS FADYNLLDLL LIHEVLAPGC LDAFPLLSAY VGRLSARPKL KAFLASPEYV NLPINGNGKQ

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

ncbi gi num :

4504183

ncbi acc num :

NP_000843.1

ncbi gb acc num :

NM_000852.3

uniprot acc num :

P09211

ncbi mol weight :

23,356 Da

ncbi pathways :

4-hydroxy-2-nonenal Detoxification Pathway (703096); Arachidonate Epoxygenase / Epoxide Hydrolase Pathway (198838); Biological Oxidations Pathway (105698); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Drug Metabolism - Cytochrome P450 Pathway (83032); Drug Metabolism - Cytochrome P450 Pathway (427); Glutathione Conjugation Pathway (105727); Glutathione Metabolism Pathway (82973)

ncbi summary :

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

uniprot summary :

GSTP1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family. Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Transferase; Other Amino Acids Metabolism - glutathione. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: extracellular space; mitochondrion; cytoplasm; plasma membrane; intracellular; cytosol; nucleus; vesicle. Molecular Function: JUN kinase binding; protein binding; glutathione transferase activity; kinase regulator activity. Biological Process: negative regulation of JNK activity; negative regulation of MAP kinase activity; central nervous system development; negative regulation of MAPKKK cascade; negative regulation of acute inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of tumor necrosis factor production; negative regulation of stress-activated MAPK cascade; regulation of stress-activated MAPK cascade; response to reactive oxygen species; negative regulation of biosynthetic process; glutathione metabolic process; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of fibroblast proliferation; xenobiotic metabolic process; positive regulation of superoxide release; negative regulation of protein kinase activity; negative regulation of apoptosis

size1 :

0.5 mg (E-Coli)

price1 :

960 USD

size2 :

0.05 mg (Baculovirus)

price2 :

960

size3 :

0.5 mg (Yeast)

price3 :

1180

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1180

size5 :

1 mg (E-Coli)

price5 :

1435

more info or order :

MyBioSource product webpage