protein

Recombinant Human Heterogeneous nuclear ribonucleoprotein H

MBS966541

0.05 mg (E-Coli)

190 USD

Recombinant Protein

Recombinant Human Heterogeneous nuclear ribonucleoprotein H

Heterogeneous nuclear ribonucleoprotein H

heterogeneous nuclear ribonucleoprotein H; Heterogeneous nuclear ribonucleoprotein H; heterogeneous nuclear ribonucleoprotein H; heterogeneous nuclear ribonucleoprotein H1 (H)

HNRNPH1

HNRNPH1; HNRNPH1; HNRPH; HNRPH1; hnRNPH; HNRPH; HNRPH1; hnRNP H

HNRH1_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-449; Full length.

449

MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNG
AQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETM
GHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRG
LPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAF
VQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHY
DPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRG
AYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSD
HRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPL
NPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKAN
MQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGG
AYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSS
MSGYDQVLQENSSDFQSNIA

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Transcription

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).

Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes.Honore B., Rasmussen H.H., Vorum H., Dejgaard K., Liu X., Gromov P., Madsen P., Gesser B., Tommerup N., Celis J.E.J. Biol. Chem. 270:28780-28789(1995)

381342476

NP_001244222.1

NM_001257293.1

P31943

65.1kD

Gene Expression Pathway (1269649); Processing Of Capped Intron-Containing Pre-mRNA Pathway (1269688); MRNA Splicing Pathway (1269689); MRNA Splicing - Major Pathway (1269690); MRNA Processing Pathway (198843)

This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

hnRNP H1: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Protein type: Spliceosome; RNA splicing; RNA-binding. Chromosomal Location of Human Ortholog: 5q35.3. Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus. Molecular Function: nucleotide binding; poly(U) binding; protein binding; RNA binding. Biological Process: gene expression; nuclear mRNA splicing, via spliceosome; regulation of RNA splicing; RNA processing; RNA splicing

0.05 mg (E-Coli)

190 USD

0.2 mg (E-Coli)

460

0.5 mg (E-Coli)

750

0.05 mg (Baculovirus)

950

0.05 mg (Mammalian-Cell)

1170