product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Sodium/hydrogen exchanger 3 (SLC9A3)
catalog :
MBS966425
quantity :
1 mg (E Coli Derived
price :
1375 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS966425
products type :
Recombinant Protein
products full name :
Recombinant Human Sodium/hydrogen exchanger 3 (SLC9A3)
products short name :
Sodium/hydrogen exchanger 3 (SLC9A3)
products name syn :
Recombinant Sodium/hydrogen exchanger 3 (SLC9A3); Sodium/hydrogen exchanger 3; Na(+)/H(+) exchanger 3; NHE-3 Solute carrier family 9 member 3
other names :
sodium/hydrogen exchanger 3; Sodium/hydrogen exchanger 3; sodium/hydrogen exchanger 3; NHE-3; Na(+)/H(+) exchanger 3; solute carrier family 9 member 3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3; Na(+)/H(+) exchanger 3; NHE-3; Solute carrier family 9 member 3
products gene name syn :
SLC9A3; NHE3
other gene names :
SLC9A3; SLC9A3; NHE3; NHE3; NHE-3
uniprot entry name :
SL9A3_HUMAN
host :
E Coli or Yeast
sequence positions :
1-834
sequence length :
834
sequence :
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGES
GGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKV
TSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFF
YLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAA
TTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVA
VLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESF
VALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLS
LVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAI
TFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIF
MFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQT
WLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGD
KVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRS
EHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKW
SHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISY
VAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSY
LLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYL
YKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLES
FKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPME
SPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVT
KDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGET
VVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADG
PEERPPAALPESTHM
purity :
>90%
form :
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)
other info2 :
Storage Buffer: PBS pH 7.4, 50% glycerol
ncbi gi num :
194239733
ncbi acc num :
NP_004165.2
ncbi gb acc num :
NM_004174.2
uniprot acc num :
P48764
ncbi mol weight :
92,855 Da
ncbi pathways :
Bile Secretion Pathway 193146!!Bile Secretion Pathway 193095!!Endothelins Pathway 137958!!Mineral Absorption Pathway 212237!!Mineral Absorption Pathway 212220!!Protein Digestion And Absorption Pathway 172847!!Protein Digestion And Absorption Pathway 171868!!Proximal Tubule Bicarbonate Reclamation Pathway 144182!!Proximal Tubule Bicarbonate Reclamation Pathway 144027!!RhoA Signaling Pathway 169356
uniprot summary :
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Subunit structure: Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels . By similarity. Ref.4. Subcellular location: Cell membrane; Multi-pass membrane protein. Note: In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Ref.4. Post-translational modification: Phosphorylated by PKA, which inhibits activity . By similarity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane . By similarity. Sequence similarities: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]. Caution: The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.
size :
1 mg (E Coli Derived)
price :
1375 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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