Recombinant Human Nuclear receptor subfamily 4 group A member 2 (NR4A2) | MyBioSource MBS966218 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Nuclear receptor subfamily 4 group A member 2 (NR4A2)

catalog :

MBS966218

quantity :

0.5 mg (E-Coli)

price :

1400 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS966218

products type :

Recombinant Protein

products full name :

Recombinant Human Nuclear receptor subfamily 4 group A member 2 (NR4A2)

products short name :

Nuclear receptor subfamily 4 group A member 2 (NR4A2)

products name syn :

Nuclear receptor subfamily 4 group A member 2; Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor

other names :

nuclear receptor subfamily 4 group A member 2; Nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4 group A member 2; nuclear receptor related 1; T-cell nuclear receptor NOT; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; intermediate-early receptor protein; immediate-early response protein NOT; nur related protein-1, human homolog of; transcriptionally-inducible nuclear receptor; NGFI-B/nur77 beta-type transcription factor homolog; transcriptionally inducible nuclear receptor related 1; nuclear receptor subfamily 4, group A, member 2; Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor

products gene name :

NR4A2

products gene name syn :

NR4A2; NOT; NURR1; TINUR

other gene names :

NR4A2; NR4A2; NOT; RNR1; HZF-3; NURR1; TINUR; NOT; NURR1; TINUR

uniprot entry name :

NR4A2_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-598

sequence length :

598

sequence :

MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

5453822

ncbi acc num :

NP_006177.1

ncbi gb acc num :

NM_006186.3

uniprot acc num :

P43354

ncbi mol weight :

59,809 Da

ncbi pathways :

Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848)

ncbi summary :

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 2q22-q23. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; protein heterodimerization activity; steroid hormone receptor activity. Biological Process: positive regulation of catalytic activity; adult locomotory behavior; neuron migration; dopamine biosynthetic process; signal transduction; response to insecticide; neuron maturation; post-embryonic development; regulation of respiratory gaseous exchange; general adaptation syndrome; negative regulation of neuron apoptosis; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; response to inorganic substance; transcription, DNA-dependent; death; response to amphetamine; regulation of dopamine metabolic process; central nervous system projection neuron axonogenesis; habenula development; response to hypoxia; cellular response to extracellular stimulus; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling. Disease: Parkinson Disease, Late-onset

size1 :

0.5 mg (E-Coli)

price1 :

1400 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1400

size3 :

0.5 mg (Yeast)

price3 :

1620

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1620

size5 :

1 mg (E-Coli)

price5 :

2340

more info or order :

MyBioSource product webpage