catalog number :
MBS966020
products type :
Recombinant Protein
products full name :
Recombinant Human Glucagon receptor (GCGR)
products short name :
Glucagon receptor (GCGR)
products name syn :
Recombinant Glucagon receptor (GCGR); Glucagon receptor; GL-R
other names :
glucagon receptor; Glucagon receptor; glucagon receptor; GL-R; glucagon receptor
products gene name syn :
GCGR
other gene names :
GCGR; GCGR; GGR; GL-R
uniprot entry name :
GLR_HUMAN
sequence positions :
26-477
sequence :
AQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDK
YSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPD
GQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQ
VMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLF
ASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGA
VAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLP
ERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSN
DNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQ
MHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGT
LRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRW
HRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGG
GSQDSSAETPLAGGLPRLAESPF
form :
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)
other info2 :
Storage Buffer: PBS pH 7.4, 50% glycerol
ncbi acc num :
NP_000151.1
ncbi gb acc num :
NM_000160.3
ncbi mol weight :
54,009 Da
ncbi pathways :
Class B/2 (Secretin Family Receptors) Pathway 106378!!G Alpha (q) Signalling Events Pathway 106043!!G Alpha (s) Signalling Events Pathway 119549!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!GPCRs, Class B Secretin-like Pathway 198781!!Gastrin-CREB Signalling Pathway Via PKC And MAPK 645295!!Glucagon Signaling In Metabolic Regulation Pathway 106097!!Glucagon-type Ligand Receptors Pathway 106380!!Integration Of Energy Metabolism Pathway 106096
ncbi summary :
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
uniprot summary :
Function: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Subcellular location: Cell membrane; Multi-pass membrane protein. Sequence similarities: Belongs to the G-protein coupled receptor 2 family.
size :
1 mg (E Coli Derived)