Recombinant Human Villin-1 (VIL1) | MyBioSource MBS965451 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Villin-1 (VIL1)

catalog :

MBS965451

quantity :

1 mg (E-Coli)

price :

1375 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS965451

products type :

Recombinant Protein

products full name :

Recombinant Human Villin-1 (VIL1)

products short name :

Villin-1 (VIL1)

products name syn :

Recombinant Villin-1 (VIL1); Villin-1

other names :

villin-1; Villin-1; villin-1; villin 1

products gene name syn :

VIL1; VIL

other gene names :

VIL1; VIL1; VIL; D2S1471; VIL

uniprot entry name :

VILI_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

2-827

sequence length :

827

sequence :

TKLSAQVKGSLNITTPGLQIWRIEAMQMVPVPSSTFGSF
FDGDCYIILAIHKTASSLSYDIHYWIGQDSSLDEQGAAA
IYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIR
KGGVASGMKHVETNSYDVQRLLHVKGKRNVVAGEVEMSW
KSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAKE
IRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRE
LKAAVPDTVVEPALKAALKLYHVSDSEGNLVVREVATRP
LTQDLLSHEDCYILDQGGLKIYVWKGKKANEQEKKGAMS
HALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTAS
NRTSGLGKTHTVGSVAKVEQVKFDATSMHVKPQVAAQQK
MVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLL
YTYLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQK
YNGEPVQIRVPMGKEPPHLMSIFKGRMVVYQGGTSRTNN
LETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFV
LKTQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVV
EGQEPANFWMALGGKAPYANTKRLQEENLVITPRLFECS
NKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFFWIGK
HANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHE
PPTFTGWFLAWDPFKWSNTKSYEDLKAELGNSRDWSQIT
AEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELP
EGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNL
KKEKGLF

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

194394237

ncbi acc num :

NP_009058.2

ncbi gb acc num :

NM_007127.2

uniprot acc num :

P09327

ncbi mol weight :

92,695 Da

ncbi pathways :

Regulation Of Actin Cytoskeleton Pathway (198874)

ncbi summary :

This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]

uniprot summary :

Villin: Epithelial cell-specific Ca(2+)-regulated actin- modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. Monomer. Homodimer; homodimerization is necessary for actin-bundling. Associates with F-actin; phosphorylation at tyrosines residues decreases the association with F-actin. Interacts (phosphorylated at C-terminus tyrosine phosphorylation sites) with PLCG1 (via the SH2 domains). Interacts (phosphorylated form) with PLCG1; the interaction is enhanced by hepatocyte growth factor (HGF). Specifically expressed in epithelial cells. Major component of microvilli of intestinal epithelial cells and kidney proximal tubule cells. Expressed in canalicular microvilli of hepatocytes. Belongs to the villin/gelsolin family. Protein type: Actin-binding; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2q35. Cellular Component: ruffle; filopodium tip; microvillus; lamellipodium; cytoplasm; actin filament bundle; filopodium. Molecular Function: actin filament binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity; caspase inhibitor activity; calcium ion binding. Biological Process: epidermal growth factor receptor signaling pathway; actin filament depolymerization; actin filament severing; actin filament capping; negative regulation of caspase activity; actin nucleation; regulation of cell shape; response to bacterium; epithelial cell differentiation; actin filament polymerization; positive regulation of actin filament bundle formation; regulation of actin nucleation; protein complex assembly; positive regulation of cell migration

size1 :

1 mg (E-Coli)

price1 :

1375 USD

size2 :

1 mg (Yeast)

price2 :

1835

more info or order :

MyBioSource product webpage