protein

Recombinant Human Zinc finger protein GLI2

MBS965174

0.02 mg (Mammalian-C

375 USD

Recombinant Protein

Recombinant Human Zinc finger protein GLI2

Zinc finger protein GLI2

GLI family zinc finger protein 2; Tax helper protein

zinc finger protein GLI2; Zinc finger protein GLI2; zinc finger protein GLI2; GLI family zinc finger 2; GLI family zinc finger protein 2

GLI2

GLI2; GLI2; CJS; HPE9; PHS2; THP1; THP2

GLI2_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

29.4KDa

1586

EQLADLKED LDRDDCKQEA EVVIYETNCH WEDCTKEYDTQEQLVHHINN EHIHGEKKEF VCRWQACTRE QKPFKAQYML VVHMRRHTGEKPHKCTFEGC SKAYSRLENL KTHLRSHTGE KPYVCEHEGC NKAFSNASDR AKHQNRTHSN EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKQRNDVHLRTPLL KENGDSEAGT EPGGPESTEA SSTSQAVEDC L

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Species: Homo sapiens (Human)

Epigenetics and Nuclear Signaling

Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal emembryonic development (PubMed:15994174, PubMed:20685856). By similarity1 Publication5 Publications Isoform 1, isoform 2, isoform 3 and isoform 4: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). Are involved in the smoothened (SHH) signaling pathway (PubMed:18455992). 3 Publications Isoform 5: Acts as a transcriptional repressor.

Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome." Tanimura A., Dan S., Yoshida M. J. Virol. 72:3958-3964(1998)

86991432

NP_005261.2

NM_005270.4

P10070

86,482 Da

Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Degradation Of GLI2 By The Proteasome Pathway (1269638); GLI Proteins Bind Promoters Of Hh Responsive Genes To Promote Transcription Pathway (1269643); Hedgehog 'off' State Pathway (1269636); Hedgehog 'on' State Pathway (1269640); Hedgehog Signaling Pathway (198835); Hedgehog Signaling Pathway (1084754); Hedgehog Signaling Pathway (1108217); Hedgehog Signaling Events Mediated By Gli Proteins Pathway (137912)

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

0.02 mg (Mammalian-Cell)

375 USD

0.05 mg (Mammalian-Cell)

715

0.5 mg (E-Coli)

985

0.05 mg (Baculovirus)

985

0.1 mg (Mammalian-Cell)

990