catalog number :
MBS964535
products type :
Recombinant Protein
products full name :
Recombinant Human T-cell surface glycoprotein CD1b (CD1B)
products short name :
T-cell surface glycoprotein CD1b (CD1B)
products name syn :
T-cell surface glycoprotein CD1b; CD_antigen=; CD1b
other names :
T-cell surface glycoprotein CD1b; T-cell surface glycoprotein CD1b; T-cell surface glycoprotein CD1b; CD1B antigen, b polypeptide; cortical thymocyte antigen CD1B; differentiation antigen CD1-alpha-3; CD1b molecule; CD_antigen: CD1b
products gene name :
CD1B
other gene names :
CD1B; CD1B; R1; CD1; CD1A
uniprot entry name :
CD1B_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
18-303
sequence :
SEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL DDLQIHGWDS DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ DFAGDFQMKY PFEIQGIAGC ELHSGGAIVS FLRGALGGLD FLSVKNASCV PSPEGGSRAQ KFCALIIQYQ GIMETVRILL YETCPRYLLG VLNAGKADLQ RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR GEQEQQGTQL GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS IGS
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
ncbi acc num :
NP_001755.1
ncbi gb acc num :
NM_001764.2
ncbi mol weight :
30,740 Da
ncbi pathways :
Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)
ncbi summary :
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]
uniprot summary :
CD1B: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q23.1. Cellular Component: cell surface; lysosomal membrane; plasma membrane; integral to membrane; endosome membrane. Molecular Function: protein binding; beta-2-microglobulin binding; exogenous lipid antigen binding; endogenous lipid antigen binding. Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; immune response