protein

Recombinant Human Creatine kinase U-type, mitochondrial

MBS963626

0.05 mg (E-Coli)

175 USD

Recombinant Protein

Recombinant Human Creatine kinase U-type, mitochondrial

Creatine kinase U-type

Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK

creatine kinase U-type, mitochondrial; Creatine kinase U-type, mitochondrial; creatine kinase U-type, mitochondrial; creatine kinase, mitochondrial 1A; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK

CKMT1B

CKMT1A; CKMT

CKMT1A; CKMT1A; CKMT1; CKMT; Mia-CK; U-MtCK

KCRU_HUMAN

E Coli

40-417

417

ASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDK
TTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEV
FADLFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDE
RYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDAL
SGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPL
LTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISM
EKGGNMKRVFERFCRGLKEVE

Greater than 90% as determined by SDS-PAGE.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Signal Transduction

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e. g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy dands, such as skeletal muscle, heart, brain and spermatozoa.

Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.Haas R.C., Korenfeld C., Zhang Z., Perryman B., Roman D., Strauss A.W.J. Biol. Chem. 264:2890-2897(1989)

66346730

NP_001015001.1

NM_001015001.1

P12532

47.2kD

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Creatine Metabolism Pathway (1270169); Creatine Pathway (413359); Creatine Pathway (468234); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158); Metabolism Of Polyamines Pathway (1270170)

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

0.05 mg (E-Coli)

175 USD

0.2 mg (E-Coli)

295

0.5 mg (E-Coli)

580

1 mg (E-Coli)

855