catalog number :
MBS963313
products type :
Recombinant Protein
products full name :
Recombinant Human Homeobox protein engrailed-1 (EN1)
products short name :
Homeobox protein engrailed-1 (EN1)
products name syn :
Homeobox protein engrailed-1; Homeobox protein en-1; Hu-En-1
other names :
homeobox protein engrailed-1; Homeobox protein engrailed-1; homeobox protein engrailed-1; hu-En-1; engrailed homolog 1; homeobox protein en-1; engrailed homeobox 1
other gene names :
EN1; EN1; Homeobox protein en-1; Hu-En-1
uniprot entry name :
HME1_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-392
sequence :
MEEQQPEPKS QRDSALGAAA AATPGGLSLS LSPGASGSSG SGSDGDSVPV SPQPAPPSPP AAPCLPPLAH HPHLPPHPPP PPPQHLAAPA HQPQPAAQLH RTTNFFIDNI LRPDFGCKKE QPPPQLLVAA AARGGAGGGG RVERDRGQTA AGRDPVHPLG TRAPGAASLL CAPDANCGPP DGSQPAAAGA GASKAGNPAA AAAAAAAAVA AAAAAAAAKP SDTGGGGSGG GAGSPGAQGT KYPEHGNPAI LLMGSANGGP VVKTDSQQPL VWPAWVYCTR YSDRPSSGPR TRKLKKKKNE KEDKRPRTAF TAEQLQRLKA EFQANRYITE QRRQTLAQEL SLNESQIKIW FQNKRAKIKK ATGIKNGLAL HLMAQGLYNH STTTVQDKDE SE
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
ncbi acc num :
NP_001417.3
ncbi gb acc num :
NM_001426.3
ncbi mol weight :
40,115 Da
ncbi pathways :
SIDS Susceptibility Pathways (198901)
ncbi summary :
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
uniprot summary :
EN1: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the engrailed (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]. Protein type: Transcription factor; Cell development/differentiation; DNA-binding. Chromosomal Location of Human Ortholog: 2q14.2. Cellular Component: membrane; nucleus. Biological Process: embryonic forelimb morphogenesis; anatomical structure morphogenesis; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; dorsal/ventral pattern formation; pigmentation; midbrain-hindbrain boundary development; midbrain development; neuron development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; proximal/distal pattern formation; hindbrain development
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)