protein

Recombinant Human Profilin-1 (PFN1)

MBS963082

0.5 mg (E-Coli)

875 USD

Recombinant Protein

Recombinant Human Profilin-1 (PFN1)

Profilin-1 (PFN1)

Profilin-1; Profilin I

profilin-1; Profilin-1; profilin-1; profilin I; epididymis tissue protein Li 184a; profilin 1; Epididymis tissue protein Li 184a; Profilin I

PFN1

PFN1; PFN1; ALS18

PROF1_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

2-140

139

AGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

4826898

NP_005013.1

NM_005022.3

P07737

15,054 Da

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); G13 Signaling Pathway (198800); Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Regulation Of Actin Cytoskeleton Pathway (198874); Regulation Of Actin Cytoskeleton Pathway (83089); Regulation Of Actin Cytoskeleton Pathway (500); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome. Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding. Chromosomal Location of Human Ortholog: 17p13.3. Cellular Component: neuron projection; focal adhesion; cytoskeleton; membrane; synapse; nucleus; cytosol. Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; Rho GTPase binding; adenyl-nucleotide exchange factor activity; actin binding; receptor binding. Biological Process: positive regulation of DNA metabolic process; platelet activation; negative regulation of actin filament bundle formation; negative regulation of stress fiber formation; negative regulation of actin filament polymerization; positive regulation of viral transcription; platelet degranulation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; neural tube closure; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; actin cytoskeleton organization and biogenesis. Disease: Amyotrophic Lateral Sclerosis 18

0.5 mg (E-Coli)

875 USD

0.05 mg (Baculovirus)

875

0.5 mg (Yeast)

1100

0.05 mg (Mammalian-Cell)

1100

1 mg (E-Coli)

1285