Recombinant Human 5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1) | MyBioSource MBS962981 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human 5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1)

catalog :

MBS962981

quantity :

1 mg (E Coli Derived

price :

1375 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS962981

products type :

Recombinant Protein

products full name :

Recombinant Human 5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1)

products short name :

5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1)

products name syn :

Storage Buffer PBS pH 7.4, 50% glycerol

other names :

5,6-dihydroxyindole-2-carboxylic acid oxidase; 5,6-dihydroxyindole-2-carboxylic acid oxidase; 5,6-dihydroxyindole-2-carboxylic acid oxidase; TRP1; TRP-1; catalase B; DHICA oxidase; glycoprotein 75; melanoma antigen gp75; tyrosinase-related protein 1; Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1

products gene name syn :

Recombinant 5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1); 5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase EC= 1.14.18.-; Catalase B Glycoprotein 75 Melanoma antigen gp75 Tyrosinase-related protein 1; TRP; TRP-1; TRP1

other gene names :

TYRP1; TYRP1; TRP; CAS2; CATB; GP75; OCA3; TYRP; SHEP11; b-PROTEIN; CAS2; TYRP; TYRRP; DHICA oxidase; TRP; TRP-1; TRP1

uniprot entry name :

TYRP1_HUMAN

host :

E Coli or Yeast

sequence positions :

25-537

sequence length :

537

sequence :

QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRG
RCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCN
GNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEK
NHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFE
NISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPA
FLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVC
DICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYD
TLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQC
LEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRS
LHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEW
LRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMF
VTAPDNLGYTYEIQWPSREFSVPEIIAIAVVGALLLVAL
IFGTASYLIRARRSMDEANQPLLTDQYQCYAEEYEKLQN
PNQSVV

purity :

>90%

form :

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

storage stability :

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

other info1 :

Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)

other info2 :

Storage Buffer: PBS pH 7.4, 50% glycerol

products description :

TYRP1; CAS2, TYRP, TYRRP

ncbi gi num :

4507757

ncbi acc num :

NP_000541.1

ncbi gb acc num :

NM_000550.2

uniprot acc num :

P17643

ncbi mol weight :

60,724 Da

ncbi pathways :

Direct P53 Effectors Pathway 137939!!Melanogenesis Pathway 83092!!Melanogenesis Pathway 504!!Tyrosine Metabolism Pathway 82959!!Tyrosine Metabolism Pathway 325!!Ethanol Degradation IV Pathway 142308!!Superoxide Radicals Degradation Pathway 142440

ncbi summary :

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

uniprot summary :

Function: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Ref.9. Cofactor: Binds 2 copper ions per subunit . By similarity. Pathway: Pigment biosynthesis; melanin biosynthesis. Subcellular location: Melanosome membrane; Single-pass type I membrane protein . By similarity. Note: Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex . By similarity. Ref.10 Ref.11. Tissue specificity: Pigment cells. Polymorphism: Genetic variants in TYRP1 define the skin/hair/eye pigmentation variation locus 11 (SHEP11) [. MIM:612271] and are responsible for variability in hair color linked to chromosome 9p23 in Melanesians. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. Involvement in disease: Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [. MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Ref.13. Sequence similarities: Belongs to the tyrosinase family.

size :

1 mg (E Coli Derived)

price :

1375 USD

more info or order :

MyBioSource product webpage