Recombinant Human Filamin-A (FLNA), partial | MyBioSource MBS962910 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Filamin-A (FLNA), partial

catalog :

MBS962910

quantity :

0.5 mg (E-Coli)

price :

1060 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS962910

products type :

Recombinant Protein

products full name :

Recombinant Human Filamin-A (FLNA), partial

products short name :

Filamin-A (FLNA), partial

products name syn :

Filamin-A; FLN-A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin

other names :

filamin-A isoform 2; Filamin-A; filamin-A; filamin-1; alpha-filamin; non-muscle filamin; actin binding protein 280; endothelial actin-binding protein; filamin A, alpha; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin

products gene name :

FLNA

products gene name syn :

FLNA; FLN; FLN1

other gene names :

FLNA; FLNA; FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280; FLN; FLN1; FLN-A; ABP-280

uniprot entry name :

FLNA_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

2-274; Actin-binding domain.

sequence length :

274

sequence :

SSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAP
WKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIA
LLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRES
IKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDE
EEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGR
ALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDW
LGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAP

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

160420317

ncbi acc num :

NP_001104026.1

ncbi gb acc num :

NM_001110556.1

uniprot acc num :

P21333

ncbi mol weight :

280,018 Da

ncbi pathways :

Androgen Receptor Signaling Pathway (198806); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-extracellular Matrix Interactions Pathway (160967); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); GP1b-IX-V Activation Signalling Pathway (187205); Hemostasis Pathway (106028); MAPK Signaling Pathway (198779)

ncbi summary :

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

uniprot summary :

FLNA: a ubiquitous cytoskeletal protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Plays an essential role in embryonic cell migration. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interactions with filamin A may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Actin-binding. Chromosomal Location of Human Ortholog: Xq28. Cellular Component: cortical cytoskeleton; focal adhesion; membrane; cell soma; perinuclear region of cytoplasm; cytoplasm; extracellular region; plasma membrane; actin filament; dendritic shaft; trans-Golgi network; cytosol; nucleus; actin cytoskeleton. Molecular Function: protein homodimerization activity; Rho GTPase binding; Rac GTPase binding; Ral GTPase binding; transcription factor binding; actin filament binding; small GTPase binding; signal transducer activity; protein binding; protein kinase C binding; mu-type opioid receptor binding; SMAD binding; glycoprotein binding. Biological Process: actin crosslink formation; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; negative regulation of transcription factor activity; receptor clustering; mRNA transcription from RNA polymerase II promoter; dopamine receptor, adenylate cyclase inhibiting pathway; establishment of protein localization; platelet degranulation; early endosome to late endosome transport; actin cytoskeleton reorganization; cytoplasmic sequestering of protein; positive regulation of transcription factor import into nucleus; epithelial to mesenchymal transition; cilium biogenesis; blood coagulation; negative regulation of protein catabolic process. Disease: Terminal Osseous Dysplasia; Fg Syndrome 2; Frontometaphyseal Dysplasia; Cardiac Valvular Dysplasia, X-linked; Melnick-needles Syndrome; Heterotopia, Periventricular, Ehlers-danlos Variant; Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-linked; Heterotopia, Periventricular, X-linked Dominant; Otopalatodigital Syndrome, Type Ii; Otopalatodigital Syndrome, Type I

size1 :

0.5 mg (E-Coli)

price1 :

1060 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1060

size3 :

0.05 mg (Mammalian-Cell)

price3 :

1290

size4 :

0.5 mg (Yeast)

price4 :

1290

size5 :

1 mg (E-Coli)

price5 :

1605

more info or order :

MyBioSource product webpage