protein

Recombinant Human Receptor-type tyrosine-protein kinase FLT3 (FLT3)

MBS962685

0.5 mg (E-Coli)

1305 USD

Recombinant Protein

Recombinant Human Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Receptor-type tyrosine-protein kinase FLT3; EC=2.7.10.1; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=; CD135

receptor-type tyrosine-protein kinase FLT3; Receptor-type tyrosine-protein kinase FLT3; receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III; fms-related tyrosine kinase 3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135

FLT3

FLT3; CD135; FLK2; STK1

FLT3; FLT3; FLK2; STK1; CD135; FLK-2; CD135; FLK2; STK1; FLK-2; FLT-3; STK-1

FLT3_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

27-543

517

NQDL PVIKCVLINH KNNDSSVGKS SSYPMVSESP EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN ISCLWVFKHS SLNCQPHFDL QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLYTLRR PYFRKMENQD ALVCISESVP EPIVEWVLCD SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE CTRLFTIDLN QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI NATNSSEDYE IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG YSISKFCNHK HQPGEYIFHA ENDDAQFTKM FTLNIRRKPQ VLAEASASQA SCFSDGYPLP SWTWKKCSDK SPNCTEEITE GVWNRKANRK VFGQWVSSST LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD NIS

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

121114304

NP_004110.2

NM_004119.2

P36888

108,378 Da

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Pathways In Cancer (83105); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]

FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Oncoprotein; TK group; PDGFR family. Chromosomal Location of Human Ortholog: 13q12. Cellular Component: protein complex; endoplasmic reticulum lumen; integral to plasma membrane; cytosol; nucleus; external side of plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; vascular endothelial growth factor receptor activity; protein binding; protein homodimerization activity; protein complex binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; glucocorticoid receptor binding. Biological Process: negative regulation of B cell differentiation; pro-B cell differentiation; lymphocyte proliferation; organ regeneration; peptidyl-tyrosine phosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; response to organic nitrogen; regulation of apoptosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAP kinase activity; negative regulation of cell proliferation; myeloid progenitor cell differentiation; positive regulation of MAPKKK cascade; positive regulation of tyrosine phosphorylation of STAT protein; B cell differentiation; positive regulation of cell proliferation; hemopoiesis; pro-T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; leukocyte homeostasis. Disease: Leukemia, Acute Lymphoblastic

0.5 mg (E-Coli)

1305 USD

0.05 mg (Baculovirus)

1305

0.5 mg (Yeast)

1525

0.05 mg (Mammalian-Cell)

1525

1 mg (E-Coli)

2150