product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Rat Neutrophil gelatinase-associated lipocalin (Lcn2)
catalog :
MBS962556
quantity :
0.5 mg (E-Coli)
price :
925 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS962556
products type :
Recombinant Protein
products full name :
Recombinant Rat Neutrophil gelatinase-associated lipocalin (Lcn2)
products short name :
Neutrophil gelatinase-associated lipocalin (Lcn2)
products name syn :
Neutrophil gelatinase-associated lipocalin; NGAL; Alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; Lipocalin-2; p25
other names :
neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; p25; NGAL; lipocalin-2; siderocalin LCN2; lipocalin 2 (oncogene 24p3); alpha-2U globulin-related protein; alpha-2-microglobulin-related protein; lipocalin 2; Alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; Lipocalin-2; Siderocalin LCN2; p25
products gene name :
Lcn2
other gene names :
Lcn2; Lcn2; Sip24; NGAL
uniprot entry name :
NGAL_RAT
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
21-198
sequence length :
178
sequence :
QDSTQNLIPA PPLISVPLQP GFWTERFQGR WFVVGLAGNA VQKERQSRFT MYSTIYELQE DNSYNVTSIL VRGQGCRYWI RTFVPSSRPG QFTLGNIHSY PQIQSYDVQV ADTDYDQFAM VFFQKTSENK QYFKVTLYGR TKGLSDELKE RFVSFAKSLG LKDNNIVFSV PTDQCIDN
purity :
>90%
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Rattus norvegicus (Rat)
ncbi gi num :
18543345
ncbi acc num :
NP_570097.1
ncbi gb acc num :
NM_130741.1
uniprot acc num :
P30152
ncbi mol weight :
22,476 Da
ncbi summary :
mouse homolog plays a role in IL3 withdrawal-induced apoptosis [RGD, Feb 2006]
uniprot summary :
LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Transporter; Secreted; Secreted, signal peptide. Cellular Component: extracellular space; cell; extracellular region; cytosol. Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding. Biological Process: response to nutrient levels; response to drug; iron ion homeostasis; cellular response to nutrient levels; response to mycotoxin; response to bacterium; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to herbicide; response to oxidative stress
size1 :
0.5 mg (E-Coli)
price1 :
925 USD
size2 :
0.05 mg (Baculovirus)
price2 :
925
size3 :
0.5 mg (Yeast)
price3 :
1145
size4 :
0.05 mg (Mammalian-Cell)
price4 :
1145
size5 :
1 mg (E-Coli)
price5 :
1375
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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