catalog number :
MBS961866
products type :
Recombinant Protein
products full name :
Recombinant Human Myelin protein P0 (MPZ)
products short name :
Myelin protein P0 (MPZ)
products name syn :
Myelin protein P0; Myelin peripheral protein; MPP; Myelin protein zero
other names :
myelin protein P0; Myelin protein P0; myelin protein P0; myelin peripheral protein; Charcot-Marie-Tooth neuropathy 1B; myelin protein zero; Myelin peripheral protein; MPP; Myelin protein zero
other gene names :
MPZ; MPZ; P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB; MPP
uniprot entry name :
MYP0_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
30-153
sequence :
I VVYTDREVHG AVGSRVTLHC SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGTFKERIQ WVGDPRWKDG SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV PTR
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
products description :
Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
ncbi acc num :
NP_000521.2
ncbi gb acc num :
NM_000530.6
ncbi mol weight :
34,387 Da
ncbi pathways :
Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Neural Crest Differentiation Pathway (672460)
ncbi summary :
This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies. [provided by RefSeq, Apr 2010]
uniprot summary :
myelin P0: a structural protein in peripheral nervous system Schwann cells. Forms an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. Defects cause of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, congenital hypomyelination neuropathy, and Roussy-Levy syndrome. Protein type: Membrane protein, integral; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 1q23.3. Cellular Component: integral to plasma membrane; plasma membrane; myelin sheath. Molecular Function: structural molecule activity. Biological Process: synaptic transmission; intercellular junction maintenance. Disease: Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive; Charcot-marie-tooth Disease, Demyelinating, Type 1b; Hypertrophic Neuropathy Of Dejerine-sottas; Charcot-marie-tooth Disease, Dominant Intermediate D; Charcot-marie-tooth Disease, Axonal, Type 2j; Charcot-marie-tooth Disease, Axonal, Type 2i; Roussy-levy Hereditary Areflexic Dystasia