catalog number :
MBS961841
products type :
Recombinant Protein
products full name :
Recombinant Mouse Disabled homolog 1 (Dab1)
products short name :
Disabled homolog 1 (Dab1)
products name syn :
Disabled homolog 1
other names :
disabled homolog 1 isoform 1; Disabled homolog 1; disabled homolog 1; yotari; disabled 1
products gene name :
Dab1
other gene names :
Dab1; Dab1; scm; scr; yot; AI956902; scrambler; C630028C02Rik
uniprot entry name :
DAB1_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-588
sequence :
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPN SQPLEDFESR FAAATPNRNL SMDFDELLEA TKVSAVTQLE LFGDMSTPPD ITSPPTPATP GDAFLPSSSQ TLPGSADVFG SMSFGTAAVP SGYVAMGAVL PSFWGQQPLV QQQIAMGAQP PVAQVIPGAQ PIAWGQPGLF PATQQAWPTV AGQFPPAAFM PTQTVMPLAA AMFQGPLTPL ATVPGTNDSA RSSPQSDKPR QKMGKESFKD FQMVQPPPVP SRKPDQPSLT CTSEAFSSYF NKVGVAQDTD DCDDFDISQL NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHVSDPTADD IFEEGFESPS KSEEQEAPDG SQASSTSDPF GEPSGEPSGD NISPQDGS
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Mus musculus (Mouse)
ncbi acc num :
NP_034144.1
ncbi gb acc num :
NM_010014.3
ncbi mol weight :
59,838 Da
ncbi pathways :
Splicing Factor NOVA Regulated Synpatic Proteins Pathway (672440)
uniprot summary :
DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons . Protein type: Adaptor/scaffold. Cellular Component: neuron projection; membrane; cell soma; perinuclear region of cytoplasm; apical part of cell; postsynaptic density; intracellular; cytosol; brush border. Molecular Function: protein binding; phospholipid binding; phosphoinositide 3-kinase binding; SH2 domain binding. Biological Process: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; nervous system development; central nervous system development; cerebellum structural organization; Golgi localization; multicellular organismal development; neuron migration; negative regulation of cell adhesion; adult walking behavior; cerebral cortex cell migration; small GTPase mediated signal transduction; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; negative regulation of astrocyte differentiation; dendrite development; negative regulation of axonogenesis; cerebral cortex radially oriented cell migration; cell differentiation; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)