catalog number :
MBS961761
products type :
Recombinant Protein
products full name :
Recombinant Human Insulin-like growth factor 1 receptor (IGF1R)
products short name :
Insulin-like growth factor 1 receptor (IGF1R)
other names :
insulin-like growth factor 1 receptor isoform 1; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
products gene name :
IGF1R
other gene names :
IGF1R; IGF1R; IGFR; CD221; IGFIR; JTK13; IGF-I receptor
uniprot entry name :
IGF1R_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
741-935
sequence :
DVMQVANTTM SSRSRNTTAA DTYNITDPEE LETEYPFFES RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIH
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)
other info2 :
Storage Buffer: Tris-based buffer,50% glycerol. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ncbi acc num :
NP_000866.1
ncbi gb acc num :
NM_000875.4
ncbi mol weight :
154,793 Da
ncbi pathways :
Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Apoptosis Pathway 198797!!Endochondral Ossification Pathway 198812!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Glioma Pathway 83110
ncbi summary :
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
size :
1 mg (E Coli Derived)