antibody

Defensin alpha1 Antibody

MBS9608844

0.1 mL

240 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Defensin alpha1 Antibody

[Defensin alpha1]

[DEF1; DEF3; DEFA1; DEFA2; DEFA3; Defensin alpha 1; Defensin alpha 2; Defensin alpha 3; HNP1; HNP3; HP1; HP3; MRS; Neutrophil defensin 1; Neutrophil defensin 2; Neutrophil defensin 3]

[neutrophil defensin 1 isoform 2 preproprotein; Neutrophil defensin 1; neutrophil defensin 1; defensin alpha 1B; Defensin, alpha 1; HNP-1; HP-1; HP1]

[DEFA1]

[DEFA1B]

[DEFA1B; DEFA1; HP1; HP-1; HNP-1; DEF1; DEFA2; MRS; HP-1; HP1; HP-2; HP2]

Polyclonal

IgG

Rabbit

Human, Mouse

94

Defensin alpha1 antibody detects endogenous levels of total Defensin alpha1

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

Liquid. Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1:1000-3000. IHC: 1:200

Western Blot (WB)

Immunohistochemistry (IHC)

Immunogen: A synthesized peptide derived from human Defensin alpha1, corresponding to a region within the internal amino acids. Similarity: Belongs to the alpha-defensin family.

Important: For Western Blot (WB), incubate membrane with diluted Ab in 5% w/v milk, 1X TBS, 0.1% Tween(R)20 at 4 degree C with gentle shaking, overnight.

Function: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Subunit Structure: Dimer (PubMed:17452329). Interacts with RETN (PubMed:15064728). Post-translational Modifications: ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production. Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation. Similarity: Belongs to the alpha-defensin family.

124248516

NP_001035965.1

NM_001042500.1

P59665

10 kDa

Alpha-defensins Pathway (530758); Cellular Roles Of Anthrax Toxin Pathway (138076); Defensins Pathway (530757); Immune System Pathway (106386); Innate Immune System Pathway (106387)

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

0.1 mL

240 USD

0.2 mL

280