protein

Recombinant Human Metabotropic glutamate receptor 5 (GRM5), partial

MBS960840

1 mg (E Coli Derived

1375 USD

Recombinant Protein

Recombinant Human Metabotropic glutamate receptor 5 (GRM5), partial

Metabotropic glutamate receptor 5 (GRM5), partial

Recombinant Metabotropic glutamate receptor 5 (GRM5), partial; Metabotropic glutamate receptor 5; mGluR5

metabotropic glutamate receptor 5 isoform b; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5; metabotropic glutamate receptor 5 variant F; metabotropic glutamate receptor 5 variant G; metabotropic glutamate receptor 5 variant H; glutamate receptor, metabotropic 5

GRM5; GPRC1E, MGLUR5

GRM5; GRM5; mGlu5; GPRC1E; MGLUR5; GPRC1E; MGLUR5; mGluR5

GRM5_HUMAN

E Coli or Yeast

>90%

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)

Storage Buffer: PBS pH 7.4, 50% glycerol

4504143

NP_000833.1

NM_000842.3

P41594

132,469 Da

Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway 106381!!GPCR Ligand Binding Pathway 161020!!GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway 198839!!Gap Junction Pathway 83072!!Gap Junction Pathway 483!!Glutamatergic Synapse Pathway 213818!!Glutamatergic Synapse Pathway 213811!!Huntington's Disease Pathway 83100

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Subunit structure: The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN . By similarity. Subcellular location: Cell membrane; Multi-pass membrane protein. Sequence similarities: Belongs to the G-protein coupled receptor 3 family.

1 mg (E Coli Derived)

1375 USD