protein

Recombinant Human Proteasome activator complex subunit 1 (PSME1)

MBS960764

1 mg (E Coli Derived

1530 USD

Recombinant Protein

Recombinant Human Proteasome activator complex subunit 1 (PSME1)

Proteasome activator complex subunit 1 (PSME1)

proteasome activator complex subunit 1 isoform 3; Proteasome activator complex subunit 1; proteasome activator complex subunit 1; IGUP I-5111; 29-kD MCP activator subunit; interferon-gamma IEF SSP 5111; 11S regulator complex subunit alpha; interferon-gamma-inducible protein 5111; interferon gamma up-regulated I-5111 protein; activator of multicatalytic protease subunit 1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); 11S regulator complex subunit alpha; REG-alpha; Activator of multicatalytic protease subunit 1; Interferon gamma up-regulated I-5111 protein; IGUP I-5111; Proteasome activator 28 subunit alpha; PA28a; PA28alpha

PSME1

PSME1; PSME1; PA28A; IFI5111; REGalpha; PA28alpha; IFI5111; REG-alpha; IGUP I-5111; PA28a; PA28alpha

PSME1_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-249

233

MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP CGPVNCNEKI VVLLQRLKPE IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TSLHTKLEGF HTQISKYFSE RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY

>90%

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)

Storage Buffer: Tris-based buffer,50% glycerol. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

PSME1; IFI5111

528078353

NP_001268457.1

NM_001281528.1

Q06323

26,870 Da

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdc20 Mediated Degradation Of Securin Pathway 105833!!APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105831!!APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway 105835!!Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105829!!Activation Of NF-kappaB In B Cells Pathway 576251!!Adaptive Immune System Pathway 366160!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Antigen Processing-Cross Presentation Pathway 477122

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

1 mg (E Coli Derived)

1530 USD