NPPA Antibody | MyBioSource MBS9607153 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NPPA Antibody

catalog :

MBS9607153

quantity :

0.1 mL

price :

240 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of PC-3, using NPPA antibody. The lane on the left is treated with the antigen-specific peptide.

image 2 :

MBS9607153 staining HepG2 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.

product information

catalog number :

MBS9607153

products type :

Antibody

products full name :

NPPA Antibody

products short name :

[NPPA]

products name syn :

[ANF; ANF_HUMAN; ANP; ATFB6; Atrial natriuretic factor; Atrial natriuretic peptide; Atriopeptin; Cardiodilatin; Cardiodilatin-related peptide; Cardionatrin; CDD ANF; CDD; CDD-ANF; CDP; Natriuretic peptide A; Natriuretic peptide precursor A; NPPA; PND; Prepronatriodilatin]

other names :

[natriuretic peptides A preproprotein; Natriuretic peptides A; natriuretic peptides A; natriuretic peptide A; CDD-ANF; Cardiodilatin; CDD]

products gene name :

[NPPA]

other gene names :

[NPPA; NPPA; ANF; ANP; CDD; CDP; PND; ATFB6; ATRST2; CDD-ANF; ANP; PND; CDD; CDP; ANF; ANP]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

151

specificity :

NPPA antibody detects endogenous levels of total NPPA

purity :

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

form :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20°C. Stable for 12 months from date of receipt.

tested application :

Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

app notes :

WB: 1:500-1:2000. IHC: 1:50-1:200. IF/ICC: 1:100-1:500

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Western Blot (WB)

image3 heading :

Immunofluorescence (IF)

other info1 :

Immunogen: A synthesized peptide derived from human NPPA. Subcellular Location: Secreted. . Similarity: Belongs to the natriuretic peptide family. Predicted Cross Reactivity : Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus . Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Xenopus (91%)

other info2 :

Conjugation: Unconjugated

products description :

The protein encoded by this gene belong to the natriuretic peptide family . Natriouretic peptides are implicated in the control of the extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursos (containing a signal peptide ), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide cardiolatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.

ncbi gi num :

23510319

ncbi acc num :

NP_006163.1

ncbi gb acc num :

NM_006172.3

uniprot acc num :

P01160

ncbi mol weight :

17 kDa

ncbi pathways :

Amyloids Pathway (366238); Disease Pathway (530764); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); HIF-1 Signaling Pathway (695200); MicroRNAs In Cardiomyocyte Hypertrophy Pathway (198784); YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway (576276)

ncbi summary :

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]

uniprot summary :

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

size1 :

0.1 mL

price1 :

240 USD

size2 :

0.2 mL

price2 :

280

more info or order :

MyBioSource product webpage