SUV39H2 Antibody | MyBioSource MBS9606178 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SUV39H2 Antibody

catalog :

MBS9606178

quantity :

0.1 mL

price :

240 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts from HuvEC using SUV39H2 antibody.

image 2 :

Western blot analysis of extracts from HepG2, using SUV39H2 Antibody. Lane 1 was treated with the antigen-specific peptide.

product information

catalog number :

MBS9606178

products type :

Antibody

products full name :

SUV39H2 Antibody

products short name :

[SUV39H2]

products name syn :

[FLJ23414; H3 K9 HMTase 2; H3-K9-HMTase 2; Histone H3 K9 methyltransferase 2; Histone H3-K9 methyltransferase 2; Histone lysine N methyltransferase H3 lysine 9 specific 2; Histone lysine N methyltransferase SUV39H2; Histone-lysine N-methyltransferase SUV39H2; KMT1B; Lysine N methyltransferase 1B; Lysine N-methyltransferase 1B; sSuppressor of variegation 3 9 homolog 2 (Drosophila); Su(var)3 9 Drosophila homolog of 2; Su(var)3 9 homolog 2; Su(var)3-9 homolog 2; Suppressor of variegation 3 9 homolog 2; Suppressor of variegation 3-9 homolog 2; Suv39h2; SUV92_HUMAN]

other names :

[histone-lysine N-methyltransferase SUV39H2 isoform 1; Histone-lysine N-methyltransferase SUV39H2; histone-lysine N-methyltransferase SUV39H2; suppressor of variegation 3-9 homolog 2; Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; Lysine N-methyltransferase 1B; Suppressor of variegation 3-9 homolog 2; Su(var)3-9 homolog 2]

products gene name :

[SUV39H2]

other gene names :

[SUV39H2; SUV39H2; KMT1B; KMT1B; H3-K9-HMTase 2; Su(var)3-9 homolog 2]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

410

specificity :

SUV39H2 antibody detects endogenous levels of total SUV39H2

purity :

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

form :

Liquid. Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 degree C. Stable for 12 months from date of receipt.

tested application :

Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

app notes :

WB: 1:500-1:1000. IF/ICC: 1:100-1:500

image1 heading :

Western Blot (WB)

image2 heading :

Immunofluorescene (IF)

image3 heading :

Western Blot (WB)

other info1 :

Immunogen: A synthesized peptide derived from human SUV39h2, corresponding to a region within the internal amino acids. Subcellular Location: Nucleus. Chromosome > Centromere. Associates with centromeric constitutive heterochromatin. Predicted Cross Reactivity : Pig, Bovine, Horse, Sheep, Rabbit, Dog . Similarity: Pig (100%), Bovine (93%), Horse (93%), Sheep (93%), Rabbit (100%), Dog (100%)

other info2 :

Conjugation: Unconjugated

products description :

Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. Subunit Structure: Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. Similarity: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

ncbi gi num :

301171588

ncbi acc num :

NP_001180353.1

ncbi gb acc num :

NM_001193424.1

uniprot acc num :

Q9H5I1

ncbi mol weight :

Observed: 46 kD. Predicted: 47 kDa

ncbi pathways :

Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320)

uniprot summary :

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

size1 :

0.1 mL

price1 :

240 USD

size2 :

0.2 mL

price2 :

280

more info or order :

MyBioSource product webpage