Recombinant Human Thioredoxin (TXN) | MyBioSource MBS960600 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Thioredoxin (TXN)

catalog :

MBS960600

quantity :

0.5 mg (E-Coli)

price :

835 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS960600

products type :

Recombinant Protein

products full name :

Recombinant Human Thioredoxin (TXN)

products short name :

Thioredoxin (TXN)

products name syn :

Thioredoxin; Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP

other names :

thioredoxin isoform 2; Thioredoxin; thioredoxin; ADF; SASP; TXN delta 3; ATL-derived factor; thioredoxin delta 3; surface-associated sulphydryl protein; thioredoxin; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP

products gene name :

TXN

products gene name syn :

TXN; TRDX; TRX; TRX1

other gene names :

TXN; TXN; TRX; TRDX; TRX1; TRDX; TRX; TRX1; Trx; ADF; SASP

uniprot entry name :

THIO_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

2-105

sequence length :

104

sequence :

VKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

349732256

ncbi acc num :

NP_001231867.1

ncbi gb acc num :

NM_001244938.1

uniprot acc num :

P10599

ncbi mol weight :

9,452 Da

ncbi pathways :

Folic Acid Network Pathway (219799); Folic Acid Network Pathway (198383); Immune System Pathway (106386); Inflammasomes Pathway (366166); Innate Immune System Pathway (106387); Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (366164); Selenium Pathway (219762); Selenium Pathway (198359)

ncbi summary :

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

uniprot summary :

TXN: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family. Protein type: Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 9q31. Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; protein disulfide oxidoreductase activity; peptide disulfide oxidoreductase activity. Biological Process: negative regulation of protein export from nucleus; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; activation of protein kinase B; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of peptidyl-serine phosphorylation; glycerol ether metabolic process; positive regulation of protein kinase B signaling cascade; cell proliferation; response to reactive oxygen species; response to radiation; cell-cell signaling; cell redox homeostasis; regulation of protein import into nucleus, translocation; innate immune response; cell motility; positive regulation of DNA binding

size1 :

0.5 mg (E-Coli)

price1 :

835 USD

size2 :

0.05 mg (Baculovirus)

price2 :

835

size3 :

0.5 mg (Yeast)

price3 :

1060

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1060

size5 :

1 mg (E-Coli)

price5 :

1200

more info or order :

MyBioSource product webpage