catalog number :
MBS960573
products type :
Recombinant Protein
products full name :
Recombinant Human Transmembrane 4 L6 family member 1
products short name :
Transmembrane 4 L6 family member 1
products name syn :
Membrane component chromosome 3 surface marker 1; Tumor-associated antigen L6
other names :
transmembrane 4 L6 family member 1; Transmembrane 4 L6 family member 1; transmembrane 4 L6 family member 1; transmembrane 4 L six family member 1; Membrane component chromosome 3 surface marker 1; Tumor-associated antigen L6
products gene name :
TM4SF1
other gene names :
TM4SF1; TM4SF1; L6; H-L6; M3S1; TAAL6; M3S1; TAAL6
uniprot entry name :
T4S1_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
115-161
sequence :
LAEGPLCLDSLGQWNYTFASTEGQYLLDTSTWSECTEPK
HIVEWNVS
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Homo sapiens (Human)
products categories :
Cancer
products references :
Cloning and expression of the tumor-associated antigen L6." Marken J.S., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A. Proc. Natl. Acad. Sci. U.S.A. 89:3503-3507(1992)
ncbi acc num :
NP_055035.1
ncbi gb acc num :
NM_014220.2
ncbi summary :
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]
uniprot summary :
TM4SF1: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular. Present in high molecular weight complexes in tumor cells. Protein type: Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q21-q25. Cellular Component: integral to plasma membrane