catalog number :
MBS9605068
products full name :
DIDO1 Antibody
products short name :
[DIDO1]
products name syn :
[BYE 1; BYE1; C20orf158; DATF 1; DATF-1; Death associated transcription factor 1; Death inducer obliterator 1; Death-associated transcription factor 1; Death-inducer obliterator 1; DIDO 1; DIDO 2; DIDO 3; DIDO1; DIDO1_HUMAN; DIDO2; DIDO3; DIO 1; DIO-1; DIO1; dJ885L7.8; DKFZp434P1115; FLJ11265; hDido 1; hDido1; KIAA0333; MGC16140]
other names :
[death-inducer obliterator 1 isoform c; Death-inducer obliterator 1; death-inducer obliterator 1; death inducer-obliterator 1; Death-associated transcription factor 1; DATF-1]
products gene name :
[DIDO1]
other gene names :
[DIDO1; DIDO1; BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8; C20orf158; DATF1; KIAA0333; DIO-1; hDido1; DATF-1]
reactivity :
Human, Mouse
specificity :
DIDO1 antibody detects endogenous levels of total DIDO1
purity :
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
form :
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
app notes :
WB: 1:500-1:1000. IF/ICC: 1:100-1:500
image1 heading :
Immunofluorescence (IF)
image2 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthesized peptide derived from human DIDO1, corresponding to a region within C-terminal amino acids. Function: Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. Similarity: The PHD-type zinc finger forms an aromatic cage around H3K4me3.
ncbi acc num :
NP_001180298.1
ncbi gb acc num :
NM_001193369.1
ncbi pathways :
Cell Cycle Pathway (530733); Chromosome Maintenance Pathway (161048); Meiosis Pathway (477133); Meiotic Synapsis Pathway (477134)
ncbi summary :
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
uniprot summary :
Putative transcription factor, weakly pro-apoptotic when overexpressed (). Tumor suppressor. Required for early embryonic stem cell development.