catalog number :
MBS9602688
products full name :
MUM1 Antibody
products short name :
[MUM1]
products name syn :
[EXPAND1; FLJ14868; FLJ22283; HSPC211; Melanoma associated antigen (mutated) 1; Melanoma ubiquitous mutated protein; MGC131891; MGC163315; MUM 1; MUM-1; MUM1; MUM1_HUMAN; Mutated melanoma associated antigen 1; Mutated melanoma-associated antigen 1; Protein expandere; PWWP domain containing protein MUM1; PWWP domain-containing protein MUM1]
other names :
[PWWP domain-containing protein MUM1; PWWP domain-containing protein MUM1; PWWP domain-containing protein MUM1; PWWP domain containing 3A, DNA repair factor; Mutated melanoma-associated antigen 1; MUM-1; Protein expandere]
products gene name :
[MUM1]
other gene names :
[PWWP3A; MUM1; MUM1; MUM-1; EXPAND1; HSPC211; EXPAND1; MUM-1]
specificity :
MUM1 antibody detects endogenous levels of total MUM1
purity :
Affinity-Chromatography
form :
Mouse igG1 in phosphate buffered saline (without Mg2+ Ca2+) pH7.4, 150mM NaCi, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20°C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
ELISA: 1:10000. WB: 1:500-1:2000. IHC: 1:200-1:1000. For Western Blot, incubate membrane with diluted primary Ab in 5% w/v milk, 1X TBS, 0.1% Tween R 20 at 4°C with gentle shaking , overnight.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Purified recombinant fragment of human MUM1 expressed in E. Coli. Subcellular Location: Nucleus. Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.
other info2 :
Similarity: The PWWP domain mediates the interaction with nucleosomes. Belong to the MUM1 family.
products description :
Description: Mutated melanoma-associated antigen 1 (MUM1) is a 78 kDa protein encoded by the MUM1 gene. MUM1 is expressed in a subset of B cells in the light zone of the germinal center, plasma cells, activated T cells and a wide spectrum of related hematolymphoid neoplasms. Antibodies to MUM1 are useful in the sub classification of lymphoid malignancies.
ncbi acc num :
NP_116242.2
ncbi gb acc num :
NM_032853.3
ncbi mol weight :
78.6 kDa
uniprot summary :
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.