catalog number :
MBS960262
products type :
Recombinant Protein
products full name :
Recombinant Human Motor neuron and pancreas homeobox protein 1 (MNX1)
products short name :
Motor neuron and pancreas homeobox protein 1 (MNX1)
products name syn :
Motor neuron and pancreas homeobox protein 1; Homeobox protein HB9
other names :
motor neuron and pancreas homeobox protein 1 isoform 2; Motor neuron and pancreas homeobox protein 1; motor neuron and pancreas homeobox protein 1; homeobox HB9; homeobox protein HB9; motor neuron and pancreas homeobox 1; Homeobox protein HB9
products gene name :
MNX1
products gene name syn :
MNX1; HLXB9
other gene names :
MNX1; MNX1; HB9; HLXB9; SCRA1; HOXHB9; HLXB9
uniprot entry name :
MNX1_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-401
sequence :
MEKSKNFRID ALLAVDPPRA ASAQSAPLAL VTSLAAAASG TGGGGGGGGA SGGTSGSCSP ASSEPPAAPA DRLRAESPSP PRLLAAHCAL LPKPGFLGAG GGGGGTGGGH GGPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYGYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP IKLGAGTFQL DQWLRASTAG MILPKMPDFN SQAQSNLLGK CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK KAKEQAAQEA EKQKGGGGGA GKGGAEEPGA EELLGPPAPG DKGSGRRLRD LRDSDPEEDE DEDDEDHFPY SNGASVHAAS SDCSSEDDSP PPRPSHQPAP Q
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
products description :
MNX1; HLXB9
ncbi acc num :
NP_001158727.1
ncbi gb acc num :
NM_001165255.1
ncbi mol weight :
20,553 Da
ncbi pathways :
Maturity Onset Diabetes Of The Young Pathway (83096); Maturity Onset Diabetes Of The Young Pathway (508)
ncbi summary :
This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
uniprot summary :
MNX1: Putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome (CURRAS). The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 7q36. Cellular Component: nucleus. Molecular Function: sequence-specific DNA binding; transcription factor activity. Biological Process: regulation of transcription from RNA polymerase II promoter; anatomical structure morphogenesis; transcription, DNA-dependent; neuron migration; spinal cord motor neuron cell fate specification; motor axon guidance; nerve development; endocrine pancreas development; humoral immune response; dorsoventral neural tube patterning; post-embryonic development. Disease: Currarino Syndrome
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)