catalog number :
MBS9600693
products full name :
Phospho-MFF (Ser172) Antibody
products short name :
[MFF]
products name syn :
[C2orf33; Chromosome 2 open reading frame 33; DKFZp666J168; GL004; Mff; MFF_HUMAN; MGC110913; Mitochondrial fission factor; OTTHUMP00000164235]
other names :
[mitochondrial fission factor isoform a; Mitochondrial fission factor; mitochondrial fission factor; mitochondrial fission factor]
products gene name :
[MFF]
other gene names :
[MFF; MFF; EMPF2; GL004; C2orf33; C2orf33]
specificity :
Phospho-MFF (Ser172) antibody detects endogenous levels of MFF.
purity :
The Ab is from purified rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns.
form :
Rabbit IgG in phosphate buffered saline pH 7.4, 150mM NaCI, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20°C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthesized peptide derived from human MFF around the phosphorylation site of Ser172. Subcellular Location: Mitochondrion Outer Membrane. Tissue Specificity: Highly expressed in heart, kidney, liver, brain, muscle, and stomach. Predicted Cross Reactivity : Rabbit . Similarity: Rabbit (86%)
other info2 :
Conjugation: Unconjugated. Epitope: Phospho Ser172
products description :
Function: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. Subunit Structure: Homodimer. Interacts with DNM1L (By similarity). Similarity: Belongs to the Tango11 family.
ncbi acc num :
NP_001263990.1
ncbi gb acc num :
NM_001277061.1
ncbi mol weight :
25; 27 kDa
ncbi summary :
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
uniprot summary :
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.