product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Solute carrier family 12 member 2 (SLC12A2), partial
catalog :
MBS960013
quantity :
1 mg (E-Coli)
price :
1375 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS960013
products type :
Recombinant Protein
products full name :
Recombinant Human Solute carrier family 12 member 2 (SLC12A2), partial
products short name :
Solute carrier family 12 member 2 (SLC12A2), partial
products name syn :
Recombinant Solute carrier family 12 member 2 (SLC12A2), partial; Solute carrier family 12 member 2; Basolateral Na-K-Cl symporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
other names :
solute carrier family 12 member 2 isoform 1; Solute carrier family 12 member 2; solute carrier family 12 member 2; basolateral Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
products gene name syn :
SLC12A2; NKCC1
other gene names :
SLC12A2; SLC12A2; BSC; BSC2; NKCC1; NKCC1
uniprot entry name :
S12A2_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
purity :
>90%
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Species: Homo sapiens (Human)
ncbi gi num :
4506975
ncbi acc num :
NP_001037.1
ncbi gb acc num :
NM_001046.2
uniprot acc num :
P55011
ncbi mol weight :
131,447 Da
ncbi pathways :
Cation-coupled Chloride Cotransporters Pathway (119563); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295); SLC-mediated Transmembrane Transport Pathway (119558); Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway (119559); Vibrio Cholerae Infection Pathway (83101); Vibrio Cholerae Infection Pathway (513)
ncbi summary :
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
uniprot summary :
NKCC1: a multi-pass membrane cation transporter protein. Aids transcellular movement of chloride across both secretory and absorptive epithelia. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Expressed in many tissues. Bumetanide is a potent NKCC1 antagonist. Two alternatively spliced isoforms have been described. Protein type: Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral. Chromosomal Location of Human Ortholog: 5q23.3. Cellular Component: membrane; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; vesicle. Molecular Function: protein binding; ammonium transmembrane transporter activity; sodium:potassium:chloride symporter activity. Biological Process: hyperosmotic response; transport; multicellular organism growth; transepithelial chloride transport; sodium ion transport; ion transport; detection of mechanical stimulus involved in sensory perception of sound; transmembrane transport; positive regulation of cell volume; potassium ion transport; gamma-aminobutyric acid signaling pathway; ammonium transport
size1 :
1 mg (E-Coli)
price1 :
1375 USD
size2 :
1 mg (Yeast)
price2 :
1835
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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