Recombinant Mouse Nuclear receptor ROR-gamma (Rorc) | MyBioSource MBS959871 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse Nuclear receptor ROR-gamma (Rorc)

catalog :

MBS959871

quantity :

0.5 mg (E-Coli)

price :

1305 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS959871

products type :

Recombinant Protein

products full name :

Recombinant Mouse Nuclear receptor ROR-gamma (Rorc)

products short name :

Nuclear receptor ROR-gamma (Rorc)

products name syn :

Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; Retinoid-related orphan receptor-gamma; Thymus orphan receptor; TOR

other names :

nuclear receptor ROR-gamma isoform 1; Nuclear receptor ROR-gamma; nuclear receptor ROR-gamma; thymus orphan receptor; nuclear receptor RZR-gamma; RAR-related orphan receptor C; retinoid-related orphan receptor-gamma; nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; Thymus orphan receptor; TOR

products gene name :

Rorc

products gene name syn :

Rorc; Nr1f3; Rorg; Thor

other gene names :

Rorc; Rorc; TOR; Thor; Nr1f3; RORgamma; Nr1f3; Rorg; Thor; TOR

uniprot entry name :

RORG_MOUSE

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-516

sequence length :

516

sequence :

MDRAPQRHHR TSRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ CNVAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK QLQQQQQQEQ VAKTPPAGSR GADTLTYTLG LSDGQLPLGA SPDLPEASAC PPGLLRASGS GPPYSNTLAK TEVQGASCHL EYSPERGKAE GRDSIYSTDG QLTLGRCGLR FEETRHPELG EPEQGPDSHC IPSFCSAPEV PYASLTDIEY LVQNVCKSFR ETCQLRLEDL LRQRTNLFSR EEVTSYQRKS MWEMWERCAH HLTEAIQYVV EFAKRLSGFM ELCQNDQIIL LTAGAMEVVL VRMCRAYNAN NHTVFFEGKY GGVELFRALG CSELISSIFD FSHFLSALCF SEDEIALYTA LVLINANRPG LQEKRRVEHL QYNLELAFHH HLCKTHRQGL LAKLPPKGKL RSLCSQHVEK LQIFQHLHPI VVQAAFPPLY KELFSTDVES PEGLSK

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Mus musculus (Mouse)

products description :

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression.

ncbi gi num :

188536040

ncbi acc num :

NP_035411.2

ncbi gb acc num :

NM_011281.3

uniprot acc num :

P51450

ncbi mol weight :

59kD

ncbi pathways :

Circadian Rhythm Pathway (83281); Circadian Rhythm Pathway (495); Gene Expression Pathway (971427); Generic Transcription Pathway (1000465); Inflammatory Bowel Disease (IBD) Pathway (842778); Inflammatory Bowel Disease (IBD) Pathway (842797); Nuclear Receptor Transcription Pathway (1000467); Nuclear Receptors Pathway (198318)

uniprot summary :

RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Nuclear receptor; DNA-binding. Cellular Component: nucleus. Molecular Function: ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding; oxysterol binding; steroid hormone receptor activity; transcription factor activity. Biological Process: Peyer s patch development; transcription, DNA-dependent; T-helper cell differentiation; regulation of fat cell differentiation; positive regulation of transcription, DNA-dependent; multicellular organismal development; mucosal-associated lymphoid tissue development; T cell differentiation in the thymus; rhythmic process; alpha-beta T cell differentiation; positive regulation of circadian rhythm; protein amino acid phosphorylation; regulation of gamma-delta T cell differentiation; lymph node development; regulation of transcription, DNA-dependent; xenobiotic metabolic process; regulation of steroid metabolic process; interleukin-17 production; steroid hormone mediated signaling; circadian regulation of gene expression; cell differentiation

size1 :

0.5 mg (E-Coli)

price1 :

1305 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1305

size3 :

0.5 mg (Yeast)

price3 :

1525

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1525

size5 :

1 mg (E-Coli)

price5 :

2150

more info or order :

MyBioSource product webpage