catalog number :
MBS959840
products type :
Recombinant Protein
products full name :
Recombinant Human Stromelysin-2 (MMP10)
products short name :
Stromelysin-2 (MMP10)
products name syn :
Stromelysin-2; SL-2; EC=3.4.24.22; Matrix metalloproteinase-10; MMP-10; Transin-2
other names :
stromelysin-2 preproprotein; Stromelysin-2; stromelysin-2; MMP-10; transin 2; transin-2; stromelysin 2; matrix metalloprotease 10; matrix metalloproteinase-10; matrix metalloproteinase 10 (stromelysin 2); matrix metallopeptidase 10 (stromelysin 2); Matrix metalloproteinase-10; MMP-10; Transin-2
products gene name :
MMP10
products gene name syn :
MMP10; STMY2
other gene names :
MMP10; MMP10; SL-2; STMY2; STMY2; SL-2; MMP-10
uniprot entry name :
MMP10_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
99-476
sequence :
FS SFPGMPKWRK THLTYRIVNY TPDLPRDAVD SAIEKALKVW EEVTPLTFSR LYEGEADIMI SFAVKEHGDF YSFDGPGHSL AHAYPPGPGL YGDIHFDDDE KWTEDASGTN LFLVAAHELG HSLGLFHSAN TEALMYPLYN SFTELAQFRL SQDDVNGIQS LYGPPPASTE EPLVPTKSVP SGSEMPAKCD PALSFDAIST LRGEYLFFKD RYFWRRSHWN PEPEFHLISA FWPSLPSYLD AAYEVNSRDT VFIFKGNEFW AIRGNEVQAG YPRGIHTLGF PPTIRKIDAA VSDKEKKKTY FFAADKYWRF DENSQSMEQG FPRLIADDFP GVEPKVDAVL QAFGFFYFFS GSSQFEFDPN ARMVTHILKS NSWLHC
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
products description :
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
ncbi acc num :
NP_002416.1
ncbi gb acc num :
NM_002425.2
ncbi mol weight :
54,151 Da
ncbi pathways :
Activation Of Matrix Metalloproteinases Pathway (576264); Degradation Of Collagen Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900)
ncbi summary :
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
uniprot summary :
MMP10: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. Belongs to the peptidase M10A family. Protein type: Secreted; EC 3.4.24.22; Protease; Extracellular matrix; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding. Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis; regulation of cell migration
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)