Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) | MyBioSource MBS958729 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

catalog :

MBS958729

quantity :

0.5 mg (E-Coli)

price :

1255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS958729

products type :

Recombinant Protein

products full name :

Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

products short name :

4-aminobutyrate aminotransferase, mitochondrial (ABAT)

products name syn :

4-aminobutyrate aminotransferase, mitochondrial; EC=2.6.1.19; (S)-3-amino-2-methylpropionate transaminase; EC=2.6.1.22; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT

other names :

4-aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate aminotransferase, mitochondrial; GABA transferase; GABA transaminase; GABA aminotransferase; 4-aminobutyrate transaminase; gamma-amino-N-butyrate transaminase; (S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase; (S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22); GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT

products gene name :

ABAT

products gene name syn :

ABAT; GABAT

other gene names :

ABAT; ABAT; GABAT; NPD009; GABA-AT; GABAT; GABA-AT; GABA transaminase; GABA-T

uniprot entry name :

GABT_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

29-500, Mature full length protein.

sequence length :

500

sequence :

SQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQN
AEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIG
YSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQ
SLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKER
GQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMG
CLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKEN
QQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGD
NHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWA
HEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIF
NTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTG
LLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIA
RNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDIL
ADFK

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

38679950

ncbi acc num :

NP_000654.2

ncbi gb acc num :

NM_000663.4

uniprot acc num :

P80404

ncbi mol weight :

56,439 Da

ncbi pathways :

4-aminobutyrate Degradation I Pathway (545335); 4-aminobutyrate Degradation I Pathway (545591); Alanine And Aspartate Metabolism Pathway (198783); Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Butanoate Metabolism Pathway (83007); Butanoate Metabolism Pathway (391); Degradation Of GABA Pathway (187177); GABA (gamma-Aminobutyrate) Shunt Pathway (413433); GABA (gamma-Aminobutyrate) Shunt Pathway (468220)

ncbi summary :

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ABAT: Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Defects in ABAT are a cause of GABA transaminase deficiency (GABATD). The phenotype of this deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Protein type: EC 2.6.1.19; Mitochondrial; Transferase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - propanoate; EC 2.6.1.22; Carbohydrate Metabolism - butanoate. Chromosomal Location of Human Ortholog: 16p13.2. Cellular Component: neuron projection; mitochondrion; mitochondrial matrix; 4-aminobutyrate transaminase complex. Molecular Function: protein homodimerization activity; succinate-semialdehyde dehydrogenase binding; (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; pyridoxal phosphate binding. Biological Process: response to nicotine; response to drug; copulation; neurotransmitter catabolic process; neurotransmitter secretion; locomotory behavior; synaptic transmission; response to ethanol; behavioral response to cocaine; response to hypoxia; negative regulation of blood pressure; gamma-aminobutyric acid catabolic process; response to iron ion. Disease: Gaba-transaminase Deficiency

size1 :

0.5 mg (E-Coli)

price1 :

1255 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1255

size3 :

0.05 mg (Mammalian-Cell)

price3 :

1485

size4 :

0.5 mg (Yeast)

price4 :

1485

size5 :

1 mg (E-Coli)

price5 :

2030

more info or order :

MyBioSource product webpage