Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A | MyBioSource MBS958677 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A

catalog :

MBS958677

quantity :

0.01 mg (E-Coli)

price :

110 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS958677

products type :

Recombinant Protein

products full name :

Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A

products short name :

DNA dC->dU-editing enzyme APOBEC-3A

products name syn :

Phorbolin-1

other names :

probable DNA dC- dU-editing enzyme APOBEC-3A; DNA dC->dU-editing enzyme APOBEC-3A; probable DNA dC- dU-editing enzyme APOBEC-3A; APOBEC3A and APOBEC3B deletion hybrid; Phorbolin-1

products gene name :

APOBEC3A

other gene names :

APOBEC3A_B; APOBEC3A; A3A

uniprot entry name :

ABC3A_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-199

sequence length :

199

sequence :

MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVER
LDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDL
VPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQEN
THVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYD
EFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQ
NQGN

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

other info2 :

Species: Homo sapiens (Human)

products categories :

Signal Transduction

products description :

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

products references :

Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1." Madsen P.P., Anant S., Rasmussen H.H., Gromov P., Vorum H., Dumanski J.P., Tommerup N., Collins J.E., Wright C.L., Dunham I., Macginnitie A.J., Davidson N.O., Celis J.E. J. Invest. Dermatol. 113:162-169(1999)

ncbi gi num :

300869638

ncbi acc num :

NP_001180218.1

ncbi gb acc num :

NM_001193289.1

uniprot acc num :

P31941

ncbi mol weight :

39kD

ncbi summary :

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. [provided by RefSeq, Jul 2012]

uniprot summary :

APOBEC3A: a single-stranded DNA cytidine deaminase involved in foreign DNA clearance with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic C-to-U hypermutation in nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Interacts with AGO2. Interacts with TRIB3. Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. Up-regulated by interferon and CpG single-stranded DNA (at protein level). Belongs to the cytidine and deoxycytidylate deaminase family. 2 isoforms of the human protein are produced by alternative initiation. Protein type: EC 3.5.4.-; Hydrolase. Chromosomal Location of Human Ortholog: 22q13.1-q13.2. Cellular Component: cytoplasm; nucleoplasm; nucleus. Molecular Function: cytidine deaminase activity; deoxycytidine deaminase activity; protein binding; zinc ion binding. Biological Process: cytidine deamination; defense response to virus; innate immune response; negative regulation of viral genome replication

size1 :

0.01 mg (E-Coli)

price1 :

110 USD

size2 :

0.05 mg (E-Coli)

price2 :

190

size3 :

0.2 mg (E-Coli)

price3 :

460

size4 :

0.5 mg (E-Coli)

price4 :

750

size5 :

0.05 mg (Baculovirus)

price5 :

945

more info or order :

MyBioSource product webpage