catalog number :
MBS958676
products type :
Recombinant Protein
products full name :
Recombinant Human ATP synthase subunit gamma, mitochondrial (ATP5C1)
products short name :
[ATP synthase subunit gamma, mitochondrial (ATP5C1)]
other names :
[ATP synthase subunit gamma, mitochondrial isoform L (liver); ATP synthase subunit gamma, mitochondrial; ATP synthase subunit gamma, mitochondrial; ATP synthase F1 subunit gamma; F-ATPase gamma subunit]
products gene name :
[ATP5C1]
other gene names :
[ATP5F1C; ATP5C1; ATP5C; ATP5C1; ATP5CL1; ATP5C; ATP5CL1]
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[26-298aa. Full Length of Mature Protein]
sequence :
ATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELK
PARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLC
GAIHSSIAKQMKSEVATLTAAGKEVMLVGIGDKIRGILY
RTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFD
EGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDD
IDADVLQNYQEYNLANIIYYSLKESTTSEQSARMTAMDN
ASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Human
other info2 :
Storage Buffer: Tris-based buffer, 50% glycerol
products description :
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.
ncbi acc num :
NP_001001973.1
ncbi gb acc num :
NM_001001973.2
ncbi mol weight :
32,881 Da
ncbi pathways :
Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Electron Transport Chain Pathway (198860); F-type ATPase, Eukaryotes Pathway (522535); Formation Of ATP By Chemiosmotic Coupling Pathway (105922); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Metabolism Pathway (477135); Oxidative Phosphorylation Pathway (82942); Oxidative Phosphorylation Pathway (303)
ncbi summary :
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]
uniprot summary :
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha3beta3. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
size5 :
0.05 mg (Baculovirus)
size8 :
0.05 mg (Mammalian-Cell)
size9 :
0.1 mg (Baculovirus)
size11 :
0.5 mg (Baculovirus)
size13 :
0.1 mg (Mammalian-Cell)
size14 :
1 mg (Baculovirus)