Recombinant Human Cytochrome P450 19A1 (CYP19A1) | MyBioSource MBS958337 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Cytochrome P450 19A1 (CYP19A1)

catalog :

MBS958337

quantity :

0.5 mg (E-Coli)

price :

1290 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS958337

products type :

Recombinant Protein

products full name :

Recombinant Human Cytochrome P450 19A1 (CYP19A1)

products short name :

Cytochrome P450 19A1 (CYP19A1)

products name syn :

Cytochrome P450 19A1; EC=1.14.14.1; Aromatase; CYPXIX; Cytochrome P-450AROM; Estrogen synthase

other names :

aromatase; Aromatase; aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens); cytochrome P450, family 19, subfamily A, polypeptide 1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase

products gene name :

CYP19A1

products gene name syn :

CYP19A1; ARO1; CYAR; CYP19

other gene names :

CYP19A1; CYP19A1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM; ARO1; CYAR; CYP19

uniprot entry name :

CP19A_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-503

sequence length :

503

sequence :

MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC LEH

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

ncbi gi num :

13904858

ncbi acc num :

NP_000094.2

ncbi gb acc num :

NM_000103.3

uniprot acc num :

P11511

ncbi mol weight :

24,518 Da

ncbi pathways :

Biological Oxidations Pathway (105698); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (413383); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (468268); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Endogenous Sterols Pathway (105701); Estrogen Biosynthesis Pathway (106155); FSH Signaling Pathway (672455); Integrated Breast Cancer Pathway (219801); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

uniprot summary :

CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Protein type: EC 1.14.14.14; Oxidoreductase; Lipid Metabolism - androgen and estrogen. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum. Molecular Function: electron carrier activity; iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding. Biological Process: steroid metabolic process; xenobiotic metabolic process; androgen metabolic process; steroid biosynthetic process; sterol metabolic process; estrogen biosynthetic process. Disease: Aromatase Deficiency; Aromatase Excess Syndrome

size1 :

0.5 mg (E-Coli)

price1 :

1290 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1290

size3 :

0.5 mg (Yeast)

price3 :

1510

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1510

size5 :

1 mg (E-Coli)

price5 :

2120

more info or order :

MyBioSource product webpage