catalog number :
MBS957464
products type :
Recombinant Protein
products full name :
Recombinant Human Mimecan
products short name :
Mimecan
products name syn :
Osteoglycin; Osteoinductive factor; OIF
other names :
mimecan isoform 2; Mimecan; mimecan; osteoglycin; Osteoglycin; Osteoinductive factor; OIF
other gene names :
OGN; OGN; OG; OIF; SLRR3A; OIF; SLRR3A; OIF
uniprot entry name :
MIME_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
21-298
sequence :
PPTQQDSRIIYDYGTDNFEESIFSQDYEDKYLDGKNIKE
KETVIIPNEKSLQLQKDEAITPLPPKKENDEMPTCLLCV
CLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAK
DFADIPNLRRLDFTGNLIEDIEDGTFSKLSLLEELSLAE
NQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNL
TFLYLDHNALESVPLNLPESLRVIHLQFNNIASITDDTF
CKANDTSYIRDRIEEIRLEGN
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Signal Transduction
products description :
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
products references :
Molecular cloning of a novel bone-forming compound
osteoinductive factor.Madisen L., Neubauer M., Plowman G., Rosen D.M., Segarini P.R., Dasch J.R., Thompson A.Y., Ziman J., Bentz H., Purchio A.F.DNA Cell Biol. 9:303-309(1990)
ncbi acc num :
NP_054776.1
ncbi gb acc num :
NM_014057.4
ncbi pathways :
Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway (1269019); Defective CHST6 Causes MCDC1 Pathway (1269020); Defective ST3GAL3 Causes MCT12 And EIEE15 Pathway (1309216); Disease Pathway (1268854); Diseases Associated With Glycosaminoglycan Metabolism Pathway (1269011); Diseases Of Glycosylation Pathway (1269010); Glycosaminoglycan Metabolism Pathway (1269972); Keratan Sulfate Biosynthesis Pathway (1269978); Keratan Sulfate Degradation Pathway (1269979); Keratan Sulfate/keratin Metabolism Pathway (1269977)
ncbi summary :
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
uniprot summary :
OGN: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9q22. Cellular Component: extracellular matrix; extracellular region; extracellular space; Golgi lumen; lysosomal lumen; proteinaceous extracellular matrix. Molecular Function: growth factor activity; heparin binding; protein binding; Roundabout binding. Biological Process: axon extension involved in axon guidance; axonogenesis; carbohydrate metabolic process; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; keratan sulfate catabolic process; keratan sulfate metabolic process; negative regulation of smooth muscle cell proliferation; regulation of axonogenesis
size4 :
0.05 mg (Baculovirus)