catalog number :
MBS957283
products type :
Recombinant Protein
products full name :
Recombinant Mouse Asialoglycoprotein receptor 2 (Asgr2), partial
products short name :
[Asialoglycoprotein receptor 2 (Asgr2)]
other names :
[asialoglycoprotein receptor 2 isoform a; Asialoglycoprotein receptor 2; asialoglycoprotein receptor 2; asialoglycoprotein receptor 2; Hepatic lectin 2; HL-2; mHL-2]
products gene name :
[Asgr2]
other gene names :
[Asgr2; Asgr2; Asgr; HL-2; ASGPR2; Asgr-2; Asgr-2; ASGP-R 2; ASGPR 2; HL-2; mHL-2]
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[80-301. Partial, provide the complete extracellular domain.]
sequence :
QSIQLQEEFRTLKETFSNFSSSTLMEFGALDTLGGSTNA
ILTSWLAQLEEKQQQLKADHSTLLFHLKHFPMDLRTLTC
QLAYFQSNGTECCPVNWVEFGGSCYWFSRDGLTWAEADQ
YCQLENAHLLVINSREEQDFVVKHRSQFHIWIGLTDRDG
SWKWVDGTDYRSNYRNWAFTQPDNWQGHEQGGGEDCAEI
LSDGHWNDNFCQQVNRWVCEKRRNITH
purity :
Greater than 85% as determined by SDS-PAGE.
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Mus musculus (Mouse)
other info2 :
Storage Buffer: Tris-based buffer, 50% glycerol
products categories :
Signal Transduction
products description :
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
products references :
Mouse asialoglycoprotein receptor cDNA sequence: conservation of receptor genes during mammalian evolution." Sanford J.P., Doyle D. Biochim. Biophys. Acta 1087:259-261(1990)
ncbi acc num :
NP_001300854.1
ncbi gb acc num :
NM_001313925.1
ncbi mol weight :
29.9 kDa
ncbi pathways :
Thyroid Hormone Synthesis Pathway (835432); Thyroid Hormone Synthesis Pathway (839541)
ncbi summary :
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Sep 2015]
uniprot summary :
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
size6 :
0.05 mg (Baculovirus)
size10 :
0.05 mg (Mammalian-Cell)
size11 :
0.1 mg (Baculovirus)
size12 :
0.1 mg (Mammalian-Cell)
size15 :
0.5 mg (Baculovirus)
size16 :
1 mg (Baculovirus)