Recombinant Mouse Wilms tumor protein homolog (Wt1) | MyBioSource MBS957212 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse Wilms tumor protein homolog (Wt1)

catalog :

MBS957212

quantity :

0.5 mg (E-Coli)

price :

1230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS957212

products type :

Recombinant Protein

products full name :

Recombinant Mouse Wilms tumor protein homolog (Wt1)

products short name :

Wilms tumor protein homolog (Wt1)

products name syn :

Wilms tumor protein homolog

other names :

Wilms tumor protein homolog; Wilms tumor protein homolog; Wilms tumor protein homolog; Wilms tumor 1 homolog

products gene name :

Wt1

products gene name syn :

Wt1; Wt-1

other gene names :

Wt1; Wt1; Wt-1; D630046I19Rik; Wt-1

uniprot entry name :

WT1_MOUSE

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-449

sequence length :

449

sequence :

MGSDVRDLNA LLPAVSSLGG GGGGCGLPVS GARQWAPVLD FAPPGASAYG SLGGPAPPPA PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTLHFSGQF TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPTIRNQGYS TVTFDGAPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGM AAGSSSSVKW TEGQSNHGIG YESENHTAPI LCGAQYRIHT HGVFRGIQDV RRVSGVAPTL VRSASETSEK RPFMCAYPGC NKRYFKLSHL QMHSRKHTGE KPYQCDFKDC ERRFSRSDQL KRHQRRHTGV KPFQCKTCQR KFSRSDHLKT HTRTHTGKTS EKPFSCRWHS CQKKFARSDE LVRHHNMHQR NMTKLHVAL

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Mus musculus (Mouse)

products description :

Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform1has lower affinity for DNA, and can bind RNA.

ncbi gi num :

139779

ncbi acc num :

P22561.1

uniprot acc num :

P22561

ncbi mol weight :

64kD

ncbi pathways :

PodNet: Protein-protein Interactions In The Podocyte Pathway (755428); Transcriptional Misregulation In Cancer Pathway (523020); Transcriptional Misregulation In Cancer Pathway (522987); XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway (755427)

ncbi summary :

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]

uniprot summary :

WT1: a DNA binding protein and apparent transcriptional regulator. Recognizes and binds to the DNA sequence 5 -CGCCCCCGC-3 . Expressed in the kidney and a subset of hematopoietic cells. Defects in WT1 are the cause of Wilms tumor 1 (WT1), an embryonal malignancy of the kidney that affects approximately 1 in 10 000 infants and young children. It occurs both in sporadic and hereditary forms. Four alternatively spliced isoforms have been described. Protein type: DNA-binding; C2H2-type zinc finger protein; Nucleolus; Tumor suppressor; Transcription factor. Cellular Component: nucleoplasm; cytoplasm; nuclear speck; nucleus. Molecular Function: protein binding; DNA binding; nucleic acid binding; zinc ion binding; sequence-specific DNA binding; RNA binding; metal ion binding; double-stranded DNA binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; tissue development; gonad development; positive regulation of apoptosis; apoptosis; positive regulation of transcription, DNA-dependent; heart development; thorax and anterior abdomen determination; negative regulation of transcription from RNA polymerase II promoter; glomerulus development; germ cell development; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; epithelial cell differentiation; ureteric bud development; single fertilization; male genitalia development; mesonephros development; vasculogenesis; kidney development; camera-type eye development; transcription, DNA-dependent; adrenal gland development; RNA splicing; male gonad development; glomerular basement membrane development; Sertoli cell development; sex determination; regulation of transcription from RNA polymerase II promoter; sperm motility; regulation of gene expression; ureteric bud branching; negative regulation of translation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; metanephros development; negative regulation of apoptosis

size1 :

0.5 mg (E-Coli)

price1 :

1230 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1230

size3 :

0.5 mg (Yeast)

price3 :

1445

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1445

size5 :

1 mg (E-Coli)

price5 :

1995

more info or order :

MyBioSource product webpage