protein

Recombinant Human X-box-binding protein 1 (XBP1)

MBS957156

0.5 mg (E-Coli)

1010 USD

Recombinant Protein

Recombinant Human X-box-binding protein 1 (XBP1)

X-box-binding protein 1 (XBP1)

X-box-binding protein 1; XBP-1; Tax-responsive element-binding protein 5

X-box-binding protein 1 isoform XBP1(S); X-box-binding protein 1; X-box-binding protein 1; tax-responsive element-binding protein 5; X-box binding protein 1; Tax-responsive element-binding protein 5

XBP1

XBP1; TREB5; XBP2

XBP1; XBP1; XBP2; TREB5; XBP-1; TREB5; XBP2; XBP-1

XBP1_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-261

261

MVVVAAAPNP ADGTPKVLLL SGQPASAAGA PAGQALPLMV PAQRGASPEA ASGGLPQARK RQRLTHLSPE EKALRRKLKN RVAAQTARDR KKARMSELEQ QVVDLEEENQ KLLLENQLLR EKTHGLVVEN QELRQRLGMD ALVAEEEAEA KGNEVRPVAG SAESAALRLR APLQQVQAQL SPLQNISPWI LAVLTLQIQS LISCWAFWTT WTQSCSSNAL PQSLPAWRSS QRSTQKDPVP YQPPFLCQWG RHQPSWKPLM N

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

118640873

NP_001073007.1

NM_001079539.1

P17861

40,148 Da

Activation Of Chaperone Genes By ATF6-alpha Pathway (530770); Activation Of Chaperone Genes By XBP1(S) Pathway (530771); Activation Of Chaperones By ATF6-alpha Pathway (105905); Activation Of Chaperones By IRE1alpha Pathway (105906); FOXA1 Transcription Factor Network Pathway (137979); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Insulin Signaling Pathway (198845); Metabolism Of Proteins Pathway (106230); Protein Processing In Endoplasmic Reticulum Pathway (167325)

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

XBP1: a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5 -GATGACGTG[TG]N(3)[AT]T-3 , and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 22q12.1 22q12. Cellular Component: nucleoplasm; endoplasmic reticulum membrane; endoplasmic reticulum; cytoplasm; integral to membrane; integral to endoplasmic reticulum membrane; cytosol; nucleus. Molecular Function: protein binding; protein homodimerization activity; DNA binding; protease binding; protein heterodimerization activity; chromatin DNA binding; ubiquitin protein ligase binding; estrogen receptor binding; protein kinase binding; transcription factor activity. Biological Process: ubiquitin-dependent protein catabolic process; transcription from RNA polymerase II promoter; phosphoinositide 3-kinase cascade; muscle development; apoptosis; exocrine pancreas development; positive regulation of transcription of target genes involved in unfolded protein response; regulation of protein stability; negative regulation of transcription from RNA polymerase II promoter; cellular response to glucose starvation; protein transport; serotonin secretion, neurotransmission; positive regulation of MHC class II biosynthetic process; positive regulation of transcription factor import into nucleus; angiogenesis; response to electrical stimulus; cell growth; positive regulation of autophagy; fatty acid biosynthetic process; positive regulation of TOR signaling pathway; response to drug; positive regulation of histone methylation; protein destabilization; unfolded protein response; organelle organization and biogenesis; cellular response to nutrient; positive regulation of immunoglobulin secretion; liver development; cholesterol homeostasis; positive regulation of immunoglobulin production; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; positive regulation of T cell differentiation; cellular response to insulin stimulus; endothelial cell proliferation; fatty acid homeostasis; neuron development; positive regulation of B cell differentiation; positive regulation of fat cell differentiation; autophagy; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; sterol homeostasis; negative regulation of apoptosis. Disease: Major Affective Disorder 7

0.5 mg (E-Coli)

1010 USD

0.05 mg (Baculovirus)

1010

0.5 mg (Yeast)

1240

0.05 mg (Mammalian-Cell)

1240

1 mg (E-Coli)

1555