Recombinant Human Decorin (DCN) | MyBioSource MBS956778 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Decorin (DCN)

catalog :

MBS956778

quantity :

0.5 mg (E-Coli)

price :

1090 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS956778

products type :

Recombinant Protein

products full name :

Recombinant Human Decorin (DCN)

products short name :

Decorin (DCN)

products name syn :

Decorin; Bone proteoglycan II; PG-S2; PG40

other names :

decorin isoform a preproprotein; Decorin; decorin; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II; decorin; Bone proteoglycan II; PG-S2; PG40

products gene name :

DCN

products gene name syn :

DCN; SLRR1B

other gene names :

DCN; DCN; CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B; SLRR1B

uniprot entry name :

PGS2_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

31-359

sequence length :

329

sequence :

DEASGIGPEV PDDRDFEPSL GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

May affect the rate of fibrils formation.

ncbi gi num :

4503271

ncbi acc num :

NP_001911.1

ncbi gb acc num :

NM_001920.3

uniprot acc num :

P07585

ncbi mol weight :

8,266 Da

ncbi pathways :

A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway (645305); CS/DS Degradation Pathway (645311); Chondroitin Sulfate Biosynthesis Pathway (645309); Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway (645308); Dermatan Sulfate Biosynthesis Pathway (645310); Disease Pathway (530764); ECM Proteoglycans Pathway (833812); Extracellular Matrix Organization Pathway (576262); Glycosaminoglycan Metabolism Pathway (645297); Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway (645304)

ncbi summary :

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]

uniprot summary :

DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Extracellular matrix; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12q21.33. Cellular Component: extracellular matrix; proteinaceous extracellular matrix; lysosomal lumen; extracellular space; Golgi lumen; extracellular region; collagen type VI. Molecular Function: collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding. Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; wound healing; response to lipopolysaccharide; pathogenesis; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; carbohydrate metabolic process; chondroitin sulfate catabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; aging; placenta development. Disease: Corneal Dystrophy, Congenital Stromal

size1 :

0.5 mg (E-Coli)

price1 :

1090 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1090

size3 :

0.5 mg (Yeast)

price3 :

1320

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1320

size5 :

1 mg (E-Coli)

price5 :

1715

more info or order :

MyBioSource product webpage