Recombinant Human C4b-binding protein alpha chain | MyBioSource MBS956295 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human C4b-binding protein alpha chain

catalog :

MBS956295

quantity :

0.01 mg (E-Coli)

price :

135 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS956295

products type :

Recombinant Protein

products full name :

Recombinant Human C4b-binding protein alpha chain

products short name :

C4b-binding protein alpha chain

products name syn :

Proline-rich protein; PRP

other names :

C4b-binding protein alpha chain; C4b-binding protein alpha chain; C4b-binding protein alpha chain; complement component 4 binding protein, alpha; Proline-rich protein; PRP

products gene name :

C4BPA

other gene names :

C4BPA; C4BPA; PRP; C4BP; C4BP; C4bp; PRP

uniprot entry name :

C4BPA_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

49-597

sequence length :

597

sequence :

NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVR
SHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEI
KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSH
PLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCD
PRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPD
VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCD
ADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDV
YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGC
EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC
HETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYK
QSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPA
PQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYG
VVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRL
MQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLD
KEL

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

other info2 :

Species: Homo sapiens (Human)

products categories :

Immunology

products description :

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

products references :

Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system." Chung L.P., Bentley D.R., Reid K.B.M. Biochem. J. 230:133-141(1985)

ncbi gi num :

4502503

ncbi acc num :

NP_000706.1

ncbi gb acc num :

NM_000715.3

uniprot acc num :

P04003

ncbi mol weight :

77.67KD

ncbi pathways :

CD40/CD40L Signaling Pathway (138061); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1269241); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Pertussis Pathway (218111); Pertussis Pathway (218099); Regulation Of Complement Cascade Pathway (1269250)

ncbi summary :

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

uniprot summary :

C4BPA: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: extracellular region; extracellular space; plasma membrane. Molecular Function: protein binding. Biological Process: complement activation, classical pathway; innate immune response; negative regulation of complement activation, classical pathway; positive regulation of protein catabolic process; regulation of complement activation

size1 :

0.01 mg (E-Coli)

price1 :

135 USD

size2 :

0.05 mg (E-Coli)

price2 :

255

size3 :

0.2 mg (E-Coli)

price3 :

665

size4 :

0.5 mg (E-Coli)

price4 :

1090

size5 :

0.05 mg (Baculovirus)

price5 :

1345

more info or order :

MyBioSource product webpage