Recombinant Human Merlin (NF2) | MyBioSource MBS956203 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Merlin (NF2)

catalog :

MBS956203

quantity :

0.5 mg (E-Coli)

price :

1395 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS956203

products type :

Recombinant Protein

products full name :

Recombinant Human Merlin (NF2)

products short name :

Merlin (NF2)

products name syn :

Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin

other names :

merlin isoform 1; Merlin; merlin; schwannomin; schwannomerlin; neurofibromin-2; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin

products gene name :

NF2

products gene name syn :

NF2; SCH

other gene names :

NF2; NF2; ACN; SCH; BANF; SCH

uniprot entry name :

MERL_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-595; Full length

sequence length :

595

sequence :

ERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEM
KWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMD
KKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHL
FFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPS
VHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEH
RGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLL
GVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTI
KPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRK
ADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAER
TRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQI
TEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQK
VLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRA
KQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSF
DFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEI
EALKLK

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

4557795

ncbi acc num :

NP_000259.1

ncbi gb acc num :

NM_000268.3

uniprot acc num :

P35240

ncbi mol weight :

24,515 Da

ncbi pathways :

ErbB2/ErbB3 Signaling Events Pathway (137955); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)

ncbi summary :

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]

uniprot summary :

Merlin: a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts. Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Tumor suppressor. Chromosomal Location of Human Ortholog: 22q12.2. Cellular Component: filopodium membrane; cortical actin cytoskeleton; early endosome; extrinsic to membrane; cytoskeleton; adherens junction; membrane; perinuclear region of cytoplasm; apical part of cell; lamellipodium; cytoplasm; nucleolus; plasma membrane; nucleus; cleavage furrow. Molecular Function: protein binding; actin binding. Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; hippocampus development; regulation of protein stability; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of cell-matrix adhesion; odontogenesis of dentine-containing teeth; negative regulation of cell proliferation; Schwann cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; ectoderm development; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of protein kinase activity; negative regulation of cell-cell adhesion; positive regulation of cell differentiation; actin cytoskeleton organization and biogenesis; negative regulation of JAK-STAT cascade; negative regulation of cell migration. Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1

size1 :

0.5 mg (E-Coli)

price1 :

1395 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1395

size3 :

0.05 mg (Mammalian-Cell)

price3 :

1625

size4 :

0.5 mg (Yeast)

price4 :

1625

size5 :

1 mg (E-Coli)

price5 :

2310

more info or order :

MyBioSource product webpage