protein

Recombinant Human 15-hydroxyprostaglandin dehydrogenase [NAD (+) ] (HPGD)

MBS956167

0.5 mg (E-Coli)

1015 USD

Recombinant Protein

Recombinant Human 15-hydroxyprostaglandin dehydrogenase [NAD (+) ] (HPGD)

15-hydroxyprostaglandin dehydrogenase [NAD (+) ] (HPGD)

15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-PGDH; EC=1.1.1.141; Prostaglandin dehydrogenase 1

15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; prostaglandin dehydrogenase 1; NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 36C, member 1; hydroxyprostaglandin dehydrogenase 15-(NAD); Prostaglandin dehydrogenase 1

HPGD

HPGD; PGDH1

HPGD; HPGD; PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1; PGDH1; 15-PGDH

PGDH_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-266

266

MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD EQFEPQKTLF IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EKTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIVG FTRSAALAAN LMNSGVRLNA ICPGFVNTAI LESIEKEENM GQYIEYKDHI KDMIKYYGIL DPPLIANGLI TLIEDDALNG AIMKITTSKG IHFQDYDTTP FQAKTQ

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

31542939

NP_000851.2

NM_000860.5

P15428

21,526 Da

Arachidonic Acid Metabolism Pathway (685553); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Prostaglandin Synthesis And Regulation Pathway (198912); Synthesis Of Lipoxins (LX) Pathway (730338); Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway (730333); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

HPGD: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 1 (PHOAR1). A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Defects in HPGD are the cause of cranioosteoarthropathy (COA). A form of osterarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC); also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Tumor suppressor; EC 1.1.1.141; Oxidoreductase. Chromosomal Location of Human Ortholog: 4q34-q35. Cellular Component: basolateral plasma membrane; cytosol. Molecular Function: protein homodimerization activity; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD binding; catalytic activity; prostaglandin E receptor activity. Biological Process: ovulation; lipoxygenase pathway; transforming growth factor beta receptor signaling pathway; cyclooxygenase pathway; arachidonic acid metabolic process; parturition; female pregnancy; negative regulation of cell cycle; prostaglandin metabolic process. Disease: Digital Clubbing, Isolated Congenital; Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1

0.5 mg (E-Coli)

1015 USD

0.05 mg (Baculovirus)

1015

0.5 mg (Yeast)

1250

0.05 mg (Mammalian-Cell)

1250

1 mg (E-Coli)

1570