catalog number :
MBS955683
products type :
Recombinant Protein
products full name :
Recombinant Mouse Insulin-like growth factor-binding protein 1
products short name :
Insulin-like growth factor-binding protein 1
other names :
insulin-like growth factor-binding protein 1; Insulin-like growth factor-binding protein 1; insulin-like growth factor-binding protein 1; insulin-like growth factor binding protein 1
products gene name :
Igfbp1
other gene names :
Igfbp1; Igfbp1; Igfbp-1; IBP-1; IGF-binding protein 1; IGFBP-1
uniprot entry name :
IBP1_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
26-272
sequence :
APQPWHCAPCTAERLGLCPPVPASCPEISRPAGCGCCPT
CALPMGAACGVATARCAQGLSCRALPGEPRPLHALTRGQ
GACVPEPAAPATSTLFSSQHEEAKAAVVSADELSESPEM
TEEQLLDSFHLMAPSREDQPILWNAISTYSSMRAREIAD
LKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPNCN
KNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETR
GDPNCHQYFNVHN
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products description :
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
products references :
cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins.Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.Mol. Cell. Endocrinol. 104:57-66(1994)
Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009)
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.Structure and localization of the IGFBP-1 gene and its expression during liver regeneration.Lee J., Greenbaum L., Haber B.A., Nagle D., Lee V., Miles V., Mohn K.L., Bucan M., Taub R.Hepatology 19:656-665(1994)
ncbi acc num :
NP_032367.3
ncbi gb acc num :
NM_008341.4
ncbi mol weight :
42.83kD
ncbi pathways :
Metabolism Of Proteins Pathway (1324154); Myometrial Relaxation And Contraction Pathways (198333); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (1324217)
uniprot summary :
IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. Protein type: Secreted; Secreted, signal peptide. Cellular Component: extracellular region; extracellular space. Molecular Function: growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding. Biological Process: regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway