catalog number :
MBS955374
products type :
Recombinant Protein
products full name :
Recombinant Rabbit Fructose-bisphosphate aldolase B
products short name :
Fructose-bisphosphate aldolase B
products name syn :
Liver-type aldolase
other names :
fructose-bisphosphate aldolase B; Fructose-bisphosphate aldolase B; fructose-bisphosphate aldolase B; Liver-type aldolase
products gene name :
ALDOB
other gene names :
ALDOB; ALDOB; ALDB; ALDB
uniprot entry name :
ALDOB_RABIT
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
2-364
sequence :
AHRFPALTPEQKKELSDIAQRIVANGKGILAADESVGTM
GNRLQRIKVENTEENRRQFREILFTVDNSINQSIGGVIL
FHETLYQKDSQGKLFRNILKEKGIVVGIKLDQGGAPLAG
TNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQ
CPSSLAIQENANTLARYASICQQNGLVPIVEPEVIPDGD
HDLEHCQYVTEKVLAAVYKALNDHHVYLEGTLLKPNMVT
AGHACTKKYTPEQVAMATVTA
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Caner
products references :
Identification of conserved promoter elements for aldB and isozyme specific residues in aldolase B.Berardini T.Z., Amsden A.B., Penhoet E.E., Tolan D.R.Comp. Biochem. Physiol. 122B:53-61(1999)
Enhanced electron-density envelopes by extended solvent definition.Blom N., Sygush J.Acta Crystallogr. D 54:461-466(1998)
ncbi acc num :
NP_001164585.1
ncbi gb acc num :
NM_001171114.1
ncbi mol weight :
55.45kD
ncbi pathways :
Biosynthesis Of Amino Acids Pathway (1072809); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (1072784); Carbon Metabolism Pathway (817567); Fructose And Mannose Metabolism Pathway (1072725); Fructose And Mannose Metabolism Pathway (291); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (1096439); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (468196); Glycolysis (Embden-Meyerhof Pathway), Glucose = Pyruvate (1096437); Glycolysis (Embden-Meyerhof Pathway), Glucose = Pyruvate (468194)
uniprot summary :
ALDOB: Defects in ALDOB are the cause of hereditary fructose intolerance (HFI). HFI is an autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. Belongs to the class I fructose-bisphosphate aldolase family. Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; Lyase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose