protein

Recombinant Human Neutrophil defensin 4 (DEFA4)

MBS954607

1 mg (E-Coli)

1375 USD

Recombinant Protein

Recombinant Human Neutrophil defensin 4 (DEFA4)

Neutrophil defensin 4 (DEFA4)

Recombinant Neutrophil defensin 4 (DEFA4); Neutrophil defensin 4; Defensin, alpha 4 HNP-4; HP-4

neutrophil defensin 4 preproprotein; Neutrophil defensin 4; neutrophil defensin 4; corticostatin; defensin, alpha 4, preproprotein; defensin, alpha 4, corticostatin; Defensin, alpha 4; HNP-4

DEFA4; DEF4

DEFA4; DEFA4; HP4; DEF4; HP-4; HNP-4; DEF4; HP-4

DEF4_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

97

vcscrlvfcrrtelrvgncliggvsftycctrv

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Homo sapiens (Human)

Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.

4503303

NP_001916.1

NM_001925.1

P12838

4.3 kDa

Alpha-defensins Pathway (530758); Defensins Pathway (530757); Immune System Pathway (106386); Innate Immune System Pathway (106387)

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Jul 2008]

DEFA4: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. Belongs to the alpha-defensin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23. Cellular Component: extracellular space; Golgi lumen; extracellular region. Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus

1 mg (E-Coli)

1375 USD

1 mg (Yeast)

1835