protein

Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

MBS954548

1 mg (E Coli Derived

1375 USD

Recombinant Protein

Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

Recombinant 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2); 3-oxo-5-alpha-steroid 4-dehydrogenase 2 EC= 1.3.99.5; 5 alpha-SR2 SR type 2 Steroid 5-alpha-reductase 2; S5AR 2 Type II 5-alpha reductase

3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; S5AR 2; SR type 2; 5 alpha-SR2; type II 5-alpha reductase; steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase

SRD5A2

SRD5A2; SRD5A2; S5AR 2

S5A2_HUMAN

E Coli or Yeast

1-254

254

MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTES
LKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGP
PGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTA
FCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILG
MGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFL
GEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRF
YLKMFEDYPKSRKALIPFIF

>90%

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)

Storage Buffer: PBS pH 7.4, 50% glycerol

39812447

NP_000339.2

NM_000348.3

P31213

28,393 Da

Androgen Biosynthesis Pathway 106154!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Metabolism Of Steroid Hormones And Vitamins A And D Pathway 106150!!Prostate Cancer Pathway 83111!!Prostate Cancer Pathway 523!!Steroid Hormone Biosynthesis Pathway 82940!!Steroid Hormone Biosynthesis Pathway 301!!Androgen Biosynthesis Pathway 545302

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]

Function: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Catalytic activity: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH. Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein . Potential. Tissue specificity: Expressed in high levels in the prostate and many other androgen-sensitive tissues. Polymorphism: Individuals with Thr-49 have an increased risk of prostate cancer. The enzyme with Thr-49 has a higher in vitro V(max) than the Ala-49 enzyme. Involvement in disease: Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [. MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18 Ref.22 Ref.23 Ref.24 Ref.25. Sequence similarities: Belongs to the steroid 5-alpha reductase family. Biophysicochemical propertiespH dependence:Optimally active at acidic pHs.

1 mg (E Coli Derived)

1375 USD