catalog number :
MBS954279
products type :
Recombinant Protein
products full name :
Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 5 (Ptpn5)
products short name :
Tyrosine-protein phosphatase non-receptor type 5 (Ptpn5)
products name syn :
Storage Buffer PBS pH 7.4, 50% glycerol
other names :
tyrosine-protein phosphatase non-receptor type 5; Tyrosine-protein phosphatase non-receptor type 5; tyrosine-protein phosphatase non-receptor type 5; neural-specific protein-tyrosine phosphatase; striatum-enriched protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5; Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase
products gene name syn :
Recombinant Tyrosine-protein phosphatase non-receptor type 5 (Ptpn5); Tyrosine-protein phosphatase non-receptor type 5 EC= 3.1.3.48; Neural-specific protein-tyrosine phosphatase Striatum-enriched protein-tyrosine phosphatase; STEP
other gene names :
Ptpn5; Ptpn5; Step; STEP
uniprot entry name :
PTN5_MOUSE
sequence positions :
1-541
sequence :
MCCSERLLGLPQPVEMEAPDEAEGLPSKQKEMPPPPPPS
PPSEPAQKLPPQGAGSHSLTVRSSLCLFAASQFLLACGV
LWLSGHGHSWLQNTTDLISSSLTVLNHLGPVAWLGSGTW
GIPSLLLVSLTVSLVIVTTLVWHLLKAPPEPPAPLPPED
RRQSVSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDC
VMDIKPETDPASLTVKSMGLQERRGSNVSLTLDMCTPGC
NEEGFGYLVSPREESAHEYLLSASRVLRAEELHEKALDP
FLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPH
SRVRLTSPDPEDPLSSYINANYIRGYSGEEKVYIATQGP
IVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPE
EQVVHDGVEITVQKVIHTEDYRLRLISLRRGTEERSLKH
YWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCSPI
IVHCSAGIGRTGCFIATSICCQQLRREGVVDILKTTCQL
RQDRGGMIQTCEQYQFVHHAMSLYEKQLSLQSSE
form :
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Mus musculus (Mouse)
other info2 :
Storage Buffer: PBS pH 7.4, 50% glycerol
products description :
Ptpn5
ncbi acc num :
NP_001157037.1
ncbi gb acc num :
NM_001163565.1
ncbi mol weight :
60,815 Da
ncbi pathways :
EGFR1 Signaling Pathway 198278!!MAPK Signaling Pathway 198294!!MAPK Signaling Pathway 83245!!MAPK Signaling Pathway 456
uniprot summary :
Function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors . By similarity. Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Subcellular location: Isoform STEP61: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.5. Isoform STEP46: Cytoplasm Ref.5. Tissue specificity: STEP20 is expressed only in the CNS. Post-translational modification: Phosphorylation at Ser-221 by PKA deactivates PTPN5. Phosphorylation at Thr-231 and Ser-244 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase . By similarity. Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.Contains 1 tyrosine-protein phosphatase domain.
size :
1 mg (E Coli Derived)