Recombinant Human Farnesyl pyrophosphate synthase | MyBioSource MBS954245 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Farnesyl pyrophosphate synthase

catalog :

MBS954245

quantity :

0.01 mg (E-Coli)

price :

135 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS954245

products type :

Recombinant Protein

products full name :

Recombinant Human Farnesyl pyrophosphate synthase

products short name :

Farnesyl pyrophosphate synthase

products name syn :

(2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Geranyltranstransferase

other names :

farnesyl pyrophosphate synthase isoform a; Farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthase; farnesyl diphosphate synthase; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Geranyltranstransferase

products gene name :

FDPS

other gene names :

FDPS; FDPS; FPS; FPPS; FPS; KIAA1293; FPP synthase; FPS

uniprot entry name :

FPPS_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-419

sequence length :

419

sequence :

MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGY
PVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQ
EKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEY
NAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW
CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAI
NDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTE
IGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFY
LPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYL
DLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQI
LKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSH
IMALIEQYAAPLPPAVFLGLARKIYKRRK

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

other info2 :

Species: Homo sapiens (Human)

products categories :

Metabolism

products description :

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

products references :

Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester." Wilkin D.J., Kutsunai S.Y., Edwards P.A. J. Biol. Chem. 265:4607-4614(1990)

ncbi gi num :

209571582

ncbi acc num :

NP_001129293.1

ncbi gb acc num :

NM_001135821.1

uniprot acc num :

P14324

ncbi mol weight :

64.24kD

ncbi pathways :

Activation Of Gene Expression By SREBF (SREBP) Pathway (1270039); Cholesterol Biosynthesis Pathway (198809); Cholesterol Biosynthesis Pathway (1270037); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Influenza A Pathway (217173); Influenza A Pathway (217150); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001)

ncbi summary :

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

uniprot summary :

FDPS: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Belongs to the FPP/GGPP synthase family. Protein type: EC 2.5.1.1; Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.10; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q22. Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm. Molecular Function: dimethylallyltranstransferase activity; geranyltranstransferase activity; metal ion binding. Biological Process: cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; viral reproduction

size1 :

0.01 mg (E-Coli)

price1 :

135 USD

size2 :

0.05 mg (E-Coli)

price2 :

255

size3 :

0.2 mg (E-Coli)

price3 :

665

size4 :

0.5 mg (E-Coli)

price4 :

1090

size5 :

0.05 mg (Baculovirus)

price5 :

1195

more info or order :

MyBioSource product webpage